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    NIT2 nitrilase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823555, updated on 18-Sep-2024

    Summary

    Official Symbol
    NIT2
    Official Full Name
    nitrilase 2
    Primary source
    TAIR:AT3G44300
    Locus tag
    AT3G44300
    See related
    Araport:AT3G44300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtNIT2; nitrilase 2; NITRILASE 2; NITRILE AMINOHYDROLASE
    Summary
    Encodes an enzyme that catalyzes the hydrolysis of indole-3-acetonitrile (IAN) to indole-3-acetic acid (IAA) (nitrile aminohydrolase, EC 3.5.5.1) and IAN to indole-3-acetamide (IAM) at lower levels. Mutants have reduced sensitivity to IAN and are sensitive to IAA. This enzyme likely participates in other non-auxin-related metabolic pathways.
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    Genomic context

    See NIT2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (15983199..15985535)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene NAC domain containing protein 60 Neighboring gene ncRNA Neighboring gene nitrilase 1 Neighboring gene nitrilase 3

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    nitrilase 2
    NP_190016.1
    • nitrilase 2 (NIT2); FUNCTIONS IN: indole-3-acetonitrile nitrilase activity, nitrilase activity, indole-3-acetonitrile nitrile hydratase activity; INVOLVED IN: response to cadmium ion, indoleacetic acid biosynthetic process, response to bacterium; LOCATED IN: cellular_component unknown; EXPRESSED IN: cotyledon, cultured cell; CONTAINS InterPro DOMAIN/s: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase (InterPro:IPR003010), Nitrilase/cyanide hydratase, conserved site (InterPro:IPR000132); BEST Arabidopsis thaliana protein match is: nitrilase 1 (TAIR:AT3G44310.3); Has 7677 Blast hits to 7598 proteins in 1742 species: Archae - 157; Bacteria - 4958; Metazoa - 446; Fungi - 568; Plants - 325; Viruses - 11; Other Eukaryotes - 1212 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      15983199..15985535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114298.3NP_190016.1  nitrilase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190016.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P32962, Q96505
      UniProtKB/TrEMBL
      A0A178V952, A0A384LD03, O04907, Q1LYZ1
      Conserved Domains (1) summary
      PLN02504
      Location:1339
      PLN02504; nitrilase