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    THFS 10-formyltetrahydrofolate synthetase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841470, updated on 18-Sep-2024

    Summary

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    Official Symbol
    THFS
    Official Full Name
    10-formyltetrahydrofolate synthetase
    Primary source
    TAIR:AT1G50480
    Locus tag
    AT1G50480
    See related
    Araport:AT1G50480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    10-formyltetrahydrofolate synthetase; 10-FORMYLTETRAHYDROFOLATE SYNTHETASE; F11F12.17
    Summary
    10-formyltetrahydrofolate synthetase (THFS) mRNA, complete
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    Genomic context

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    See THFS in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (18701882..18704938)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene hexokinase-like 1 Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene ubiquitin-conjugating enzyme 20 Neighboring gene Membrane trafficking VPS53 family protein Neighboring gene indigoidine synthase A family protein Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 27 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteomic survey of copper-binding proteins in Arabidopsis roots by immobilized metal affinity chromatography and mass spectrometry. Kung CC, et al. Proteomics, 2006 May. PMID 16526091
    2. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804
    3. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    4. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_103931.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding HDA PubMed 
    enables formate-tetrahydrofolate ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    10-formyltetrahydrofolate synthetase
    NP_564571.1
    • 10-formyltetrahydrofolate synthetase (THFS); FUNCTIONS IN: formate-tetrahydrofolate ligase activity, copper ion binding, ATP binding; INVOLVED IN: response to cadmium ion, folic acid and derivative biosynthetic process; LOCATED IN: apoplast, chloroplast, plasma membrane; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Formate-tetrahydrofolate ligase, FTHFS, conserved site (InterPro:IPR020628), Formate-tetrahydrofolate ligase, FTHFS (InterPro:IPR000559); BEST Arabidopsis thaliana protein match is: P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR:AT2G12280.1); Has 7211 Blast hits to 7172 proteins in 1581 species: Archae - 30; Bacteria - 3794; Metazoa - 307; Fungi - 186; Plants - 64; Viruses - 0; Other Eukaryotes - 2830 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18701882..18704938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103931.4 → NP_564571.1  10-formyltetrahydrofolate synthetase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564571.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SPK5
      UniProtKB/TrEMBL
      A0A178WCW8
      Conserved Domains (1) summary
      PLN02759
      Location:1 → 634
      PLN02759; Formate--tetrahydrofolate ligase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SPK5.1

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