Slc15a4 solute carrier family 15, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc15a4provided by MGI
Official Full Name: solute carrier family 15, member 4provided by MGI
Primary source: MGI:MGI:2140796
See related: Ensembl:ENSMUSG00000029416 AllianceGenome:MGI:2140796
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PHT1; PTR4; C130069N12Rik
Summary: Enables L-histidine transmembrane transporter activity and peptide:proton symporter activity. Involved in several processes, including L-histidine transmembrane export from vacuole; positive regulation of pattern recognition receptor signaling pathway; and regulation of isotype switching to IgG isotypes. Located in early endosome membrane and lysosomal membrane. Is expressed in embryo. Orthologous to human SLC15A4 (solute carrier family 15 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 27.6), mammary gland adult (RPKM 16.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G1.2; 5 66.0 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (127668795..127710356, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (127594545..127633292, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells.
Title: The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells.
The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid-sensing TLRs and ligands to endolysosomes.
Title: The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid-sensing TLRs and ligands to endolysosomes.
The peptide symporter SLC15a4 is essential for the development of systemic lupus erythematosus in murine models.
Title: The peptide symporter SLC15a4 is essential for the development of systemic lupus erythematosus in murine models.
A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice.
Title: A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice.
this study shows that SLC15A4 mediates the transport of bacterially derived di/tripeptides to enhance the nucleotide-binding oligomerization domain-dependent immune response in mouse bone marrow-derived macrophages
Title: SLC15A2 and SLC15A4 Mediate the Transport of Bacterially Derived Di/Tripeptides To Enhance the Nucleotide-Binding Oligomerization Domain-Dependent Immune Response in Mouse Bone Marrow-Derived Macrophages.
this study demonstrated that SLC15A4 is required for mast-cell secretory-granule homeostasis, and limits mast-cell functions and inflammatory responses by controlling the mTORC1-TFEB signaling axis
Title: Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells.
Slc15a4 is required for intact function of TLR9-expressing cells and for effective antibody isotype switching to IgG2c.
Title: Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation.
SLC15A4-mediated optimization of the endolysosomal state is integral to a Toll-like receptor 7-triggered, mTOR-dependent interferon regulatory factor 7-type I interferon circuit that leads to autoantibody production.
Title: The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production.
We found marked changes in protein expression and functional activity of PhT1 and PepT2, the former predominating in adult and the latter in neonate
Title: Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat.
the feeble mutation (Slc15a4) affecting Plasmacytoid dendritic cells is dispensable for immunity during an acute infection; however, data show that feeble mice failed to control a chronic infection
Title: Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235324

Slc15a4 (e-PCR), detects polymorphism
- UniSTS:546998

AA987064 (e-PCR)
- UniSTS:159448

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-histidine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-histidine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-histidine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-histidine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dipeptide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dipeptide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide:proton symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptide:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables peptidoglycan transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables peptidoglycan transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-histidine transmembrane export from vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dipeptide import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in dipeptide import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in dipeptide import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in histidine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in histidine transport	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in mast cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan transport	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidoglycan transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of toll-like receptor 7 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 7 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 8 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of toll-like receptor 8 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 9 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 9 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of isotype switching to IgG isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endolysosome membrane	ISO Inferred from Sequence Orthology more info
located_in endolysosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: solute carrier family 15 member 4

Names: peptide transporter 4; peptide-histidine transporter 4; peptide/histidine transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133895.1 → NP_598656.1 solute carrier family 15 member 4

See identical proteins and their annotated locations for NP_598656.1

Status: PROVISIONAL

Source sequence(s)

BC016233

Consensus CDS

CCDS19688.1

UniProtKB/Swiss-Prot

Q7TPL5, Q91W98

Related

ENSMUSP00000031367.9, ENSMUST00000031367.15

Conserved Domains (1) summary

pfam00854
Location:146 → 519

PTR2; POT family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

127668795..127710356 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504272.5 → XP_006504335.1 solute carrier family 15 member 4 isoform X2

Conserved Domains (1) summary

cl28910
Location:16 → 388

MFS; Major Facilitator Superfamily
XM_006504271.4 → XP_006504334.1 solute carrier family 15 member 4 isoform X1

Conserved Domains (1) summary

cl28910
Location:27 → 504

MFS; Major Facilitator Superfamily