CUL3B cullin 3B [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CUL3B
Official Full Name: cullin 3B
Primary source: TAIR:AT1G69670
Locus tag: AT1G69670
See related: Araport:AT1G69670
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA CULLIN 3B; ATCUL3B; cullin 3B; T6C23.13; T6C23_13
Summary: cullin, putative, contains similarity to Cullin homolog 3 (CUL-3) SP:Q13618, GI:3639052 from (Homo sapiens); contains Pfam profile PF00888: Cullin family. Interacts with members of AtBPM family and RBX1 suggesting it is part of an E3 ligase complex involved in RUB modification.
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Genomic context

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See CUL3B in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 3

Sequence:: Chromosome: 1; NC_003070.9 (26201986..26204795, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that CUL3 and BPM proteins assemble in planta with WRI1.
Title: Arabidopsis BPM proteins function as substrate adaptors to a cullin3-based E3 ligase to affect fatty acid metabolism in plants.
work highlights that CUL3 is essential for the normal division and organisation of the root stem cell niche and columella root cap cells
Title: Arabidopsis CULLIN3 genes regulate primary root growth and patterning by ethylene-dependent and -independent mechanisms.
Arabidopsis CUL3B gene is essential for normal embryogenesis.
Title: Arabidopsis CUL3A and CUL3B genes are essential for normal embryogenesis.
AtCUL3a and AtCUL3b can assemble in Arabidopsis with BTB/POZ-MATH and AtRBX1 proteins to form functional E3 ligases. [CUL3b]
Title: Arabidopsis AtCUL3a and AtCUL3b form complexes with members of the BTB/POZ-MATH protein family.
CUL3a and CUL3b are essential for plant development [CUL3b]
Title: Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001334418.1

Supported by ESTs:

NM_105635.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endosperm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
NOT part_of SCF ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
part_of ubiquitin ligase complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: cullin 3B

NP_001319357.1

cullin 3B (CUL3B); CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Cullin homology (InterPro:IPR016158), Cullin protein, neddylation domain (InterPro:IPR019559), Cullin, N-terminal (InterPro:IPR001373), Cullin repeat-like-containing domain (InterPro:IPR016159); BEST Arabidopsis thaliana protein match is: cullin 3 (TAIR:AT1G26830.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

26201986..26204795 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001334418.1 → NP_001319357.1 cullin 3B [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q711G4, Q9C9L0

UniProtKB/TrEMBL

A0A178W8F2, A0A654EMI3

Conserved Domains (2) summary

pfam00888
Location:29 → 630

Cullin; Cullin family

pfam10557
Location:662 → 721

Cullin_Nedd8; Cullin protein neddylation domain
NM_105635.4 → NP_177125.3 cullin 3B [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_177125.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q711G4, Q9C9L0

UniProtKB/TrEMBL

A0A178W8F2, A0A654EMI3

Conserved Domains (2) summary

pfam00888
Location:29 → 630

Cullin; Cullin family

pfam10557
Location:662 → 721

Cullin_Nedd8; Cullin protein neddylation domain