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    Scel sciellin [ Mus musculus (house mouse) ]

    Gene ID: 64929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Scelprovided by MGI
    Official Full Name
    sciellinprovided by MGI
    Primary source
    MGI:MGI:1891228
    See related
    Ensembl:ENSMUSG00000022123 AllianceGenome:MGI:1891228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9230114I02Rik
    Summary
    Predicted to enable metal ion binding activity. Involved in embryo development and epidermis development. Located in cytoplasm. Is expressed in several structures, including amnion; brain; genitourinary system; and skin. Orthologous to human SCEL (sciellin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 2.3), limb E14.5 (RPKM 1.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Scel in Genome Data Viewer
    Location:
    14 E2.3; 14 52.51 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (103750499..103850782)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (103513061..103613346)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700087I21 gene Neighboring gene STARR-seq mESC enhancer starr_37502 Neighboring gene STARR-seq mESC enhancer starr_37503 Neighboring gene STARR-positive B cell enhancer ABC_E10840 Neighboring gene STARR-positive B cell enhancer ABC_E5464 Neighboring gene predicted gene, 34907 Neighboring gene STARR-seq mESC enhancer starr_37505 Neighboring gene STARR-seq mESC enhancer starr_37506 Neighboring gene STARR-seq mESC enhancer starr_37507 Neighboring gene STARR-positive B cell enhancer ABC_E10841 Neighboring gene SLAIN motif family, member 1 Neighboring gene STARR-seq mESC enhancer starr_37509 Neighboring gene SLAIN motif family, member 1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_37510 Neighboring gene predicted gene, 35197 Neighboring gene predicted gene, 35116

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties. Champliaud MF, et al. Genomics, 2000 Dec 1. PMID 11112355
    2. Targeted deletion of the sciellin gene resulted in normal development and maturation. Baden HP, et al. Genesis, 2005 Aug. PMID 16028229
    3. Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice. Burgess RW, et al. Mol Cell Biol, 2004 Feb. PMID 14729956, Free PMC Article
    4. Functional and comparative genomic analysis of the piebald deletion region of mouse chromosome 14. Peterson KA, et al. Genomics, 2002 Aug. PMID 12160731
    5. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC132819, MGC132820

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epidermis development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epidermis development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sciellin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022886.2 → NP_075024.2  sciellin

      See identical proteins and their annotated locations for NP_075024.2

      Status: VALIDATED

      Source sequence(s)
      AC125201, AF245700, BY775767
      Consensus CDS
      CCDS37002.1
      UniProtKB/Swiss-Prot
      Q9CTT9, Q9EQG3
      UniProtKB/TrEMBL
      Q14DQ7, Q14DU0
      Related
      ENSMUSP00000093233.4, ENSMUST00000095576.5
      Conserved Domains (1) summary
      smart00132
      Location:584 → 642
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      103750499..103850782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519356.4 → XP_006519419.1  sciellin isoform X2

      UniProtKB/TrEMBL
      Q14DQ7
      Conserved Domains (1) summary
      smart00132
      Location:583 → 641
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    2. XM_006519355.5 → XP_006519418.1  sciellin isoform X1

      See identical proteins and their annotated locations for XP_006519418.1

      UniProtKB/Swiss-Prot
      Q9CTT9, Q9EQG3
      UniProtKB/TrEMBL
      Q14DQ7, Q14DU0
      Conserved Domains (1) summary
      smart00132
      Location:584 → 642
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQG3.2 GenPept UniProtKB/Swiss-Prot:Q9EQG3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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