Lats2 large tumor suppressor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lats2provided by MGI
Official Full Name: large tumor suppressor 2provided by MGI
Primary source: MGI:MGI:1354386
See related: Ensembl:ENSMUSG00000021959 Ensembl:ENSMUSG00000114942 AllianceGenome:MGI:1354386
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4932411G09Rik
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in G1/S transition of mitotic cell cycle; negative regulation of protein localization to nucleus; and regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and negative regulation of canonical Wnt signaling pathway. Located in spindle pole. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human LATS2 (large tumor suppressor kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 26.6), lung adult (RPKM 25.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 30.28 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (57927119..57983669, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (57689662..57746212, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proximal Tubular Lats2 Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53.
Title: Proximal Tubular Lats2 Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53.
Lats2 deficiency protects the heart against myocardial infarction by reducing inflammation and inhibiting mitochondrial fission and STING/p65 signaling.
Title: Lats2 deficiency protects the heart against myocardial infarction by reducing inflammation and inhibiting mitochondrial fission and STING/p65 signaling.
Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate.
Title: Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate.
LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation.
Title: LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation.
Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload.
Title: Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload.
Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma.
Title: Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma.
Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis.
Title: Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis.
MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2.
Title: MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2.
A single copy of large tumor suppressor 1 or large tumor suppressor 2 is sufficient for normal hematopoiesis.
Title: A single copy of large tumor suppressor 1 or large tumor suppressor 2 is sufficient for normal hematopoiesis.
The tumor suppressor LATS2 reduces v-Src-induced membrane blebs in a kinase activity-independent manner.
Title: The tumor suppressor LATS2 reduces v-Src-induced membrane blebs in a kinase activity-independent manner.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lats2 (e-PCR), detects polymorphism
- UniSTS:495970

AW228608 (e-PCR)
- UniSTS:180673

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within inner cell mass cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner cell mass cellular morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within keratinocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of organ growth	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase LATS2

Names: kinase phosphorylated during mitosis protein; large tumor suppressor homolog 2; serine/threonine-protein kinase kpm

NP_056586.2

EC 2.7.11.1

NP_700431.1

EC 2.7.11.1

XP_006519287.1

EC 2.7.11.1

XP_006519288.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015771.2 → NP_056586.2 serine/threonine-protein kinase LATS2 isoform 1

See identical proteins and their annotated locations for NP_056586.2

Status: VALIDATED

Description

Transcript Variant: This variant (A) represents the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

BC053028, BU705730

Consensus CDS

CCDS27158.1

UniProtKB/Swiss-Prot

Q7TSJ6, Q8CDJ4, Q9JMI3

UniProtKB/TrEMBL

G3UY78

Related

ENSMUSP00000022531.8, ENSMUST00000022531.14

Conserved Domains (3) summary

smart00220
Location:626 → 931

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14398
Location:100 → 140

UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2

cl21453
Location:624 → 1004

PKc_like; Protein Kinases, catalytic domain
NM_153382.1 → NP_700431.1 serine/threonine-protein kinase LATS2 isoform 2

See identical proteins and their annotated locations for NP_700431.1

Status: VALIDATED

Description

Transcript Variant: This variant (B) lacks the first exon, most of the 3' coding region and uses a different terminal exon compared to variant A. The resulting protein (isoform 2, also called LATS2B) is much shorter and has a distinct C-terminus when it is compared to isoform 1.

Source sequence(s)

AC154504, BF147719

Consensus CDS

CCDS49508.1

UniProtKB/TrEMBL

Q8VHE2

Related

ENSMUSP00000077130.7, ENSMUST00000077981.7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

57927119..57983669 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519224.4 → XP_006519287.1 serine/threonine-protein kinase LATS2 isoform X1

UniProtKB/TrEMBL

G3UXG3

Related

ENSMUSP00000133680.2, ENSMUST00000174694.8

Conserved Domains (3) summary

PHA03247
Location:150 → 513

PHA03247; large tegument protein UL36; Provisional

cd14398
Location:100 → 140

UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2

cl21453
Location:624 → 847

PKc_like; Protein Kinases, catalytic domain
XM_006519225.4 → XP_006519288.1 serine/threonine-protein kinase LATS2 isoform X2

See identical proteins and their annotated locations for XP_006519288.1

UniProtKB/TrEMBL

Q8VHE2