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    FZL FZO-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839566, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FZL
    Official Full Name
    FZO-like protein
    Primary source
    TAIR:AT1G03160
    Locus tag
    AT1G03160
    See related
    Araport:AT1G03160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F10O3.1; F10O3_1; FZO-like
    Summary
    A new plant-specific member of the dynamin superfamily; defines a new protein class within the dynamin superfamily of membrane remodeling GTPases that regulates organization of the thylakoid network in plants. Targeted to chloroplasts and associated with thylakoid and envelope membranes as punctate structures. Knockout mutants have abnormalities in chloroplast and thylakoid morphology, including disorganized grana stacks and alterations in the relative proportions of grana and stroma thylakoids. Overexpression of FZL-GFP also conferred defects in thylakoid organization.
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    Genomic context

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    See FZL in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (761261..766194)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Acyl-CoA N-acyltransferases (NAT) superfamily protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene FANTASTIC four-like protein (DUF3049)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Role of the FUZZY ONIONS LIKE Gene in Regulating Cell Death and Defense in Arabidopsis. Tremblay A, et al. Sci Rep, 2016 Nov 29. PMID 27898102, Free PMC Article
    2. A mutation in the FZL gene of Arabidopsis causing alteration in chloroplast morphology results in a lesion mimic phenotype. Landoni M, et al. J Exp Bot, 2013 Nov. PMID 23963675, Free PMC Article
    3. FZL, an FZO-like protein in plants, is a determinant of thylakoid and chloroplast morphology. Gao H, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16617119, Free PMC Article
    4. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data suggest that the Arabidopsis FZL gene is a negative regulator of cell death and disease resistance, possibly through regulating reactive oxygen species and autophagy pathways in the chloroplast.
      Title: A Role of the FUZZY ONIONS LIKE Gene in Regulating Cell Death and Defense in Arabidopsis.
    2. The characterization of an Arabidopsis lesion mimic mutant lacking the function of the FZL gene is reported.
      Title: A mutation in the FZL gene of Arabidopsis causing alteration in chloroplast morphology results in a lesion mimic phenotype.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001083983.1
    NM_001331388.1
    NM_001331389.1
    NM_100198.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thylakoid membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FZO-like protein
    NP_001077452.1
    • FZO-like (FZL); FUNCTIONS IN: thiamin-phosphate diphosphorylase activity, GTP binding, GTPase activity; INVOLVED IN: vegetative to reproductive phase transition of meristem, thylakoid membrane organization; LOCATED IN: chloroplast membrane, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine monophosphate synthase (InterPro:IPR003733), Protein synthesis factor, GTP-binding (InterPro:IPR000795); Has 4303 Blast hits to 3755 proteins in 1119 species: Archae - 53; Bacteria - 3491; Metazoa - 428; Fungi - 84; Plants - 61; Viruses - 0; Other Eukaryotes - 186 (source: NCBI BLink).
    NP_171815.3
    • FZO-like (FZL); FUNCTIONS IN: thiamin-phosphate diphosphorylase activity, GTP binding; INVOLVED IN: vegetative to reproductive phase transition of meristem, thylakoid membrane organization; LOCATED IN: chloroplast membrane, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiamine monophosphate synthase (InterPro:IPR003733), GTP-binding protein, HSR1-related (InterPro:IPR002917); Has 4318 Blast hits to 3768 proteins in 1124 species: Archae - 53; Bacteria - 3501; Metazoa - 428; Fungi - 84; Plants - 66; Viruses - 0; Other Eukaryotes - 186 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      761261..766194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100198.5 → NP_171815.3  FZO-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171815.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1KPV0, Q67Z21, Q6NQ84, Q9SA53, Q9ZVR8
      UniProtKB/TrEMBL
      A0A654E8G4, A0A7G2DRH1
      Conserved Domains (2) summary
      cd09912
      Location:350 → 566
      DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
      cl21457
      Location:96 → 212
      TIM; TIM-like beta/alpha barrel domains

    2. NM_001331388.1 → NP_001322638.1  FZO-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AUL2

    3. NM_001331389.1 → NP_001322639.1  FZO-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AUL4, A0A7G2DRH1

    4. NM_001083983.1 → NP_001077452.1  FZO-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1KPV0
      Conserved Domains (2) summary
      cd09912
      Location:350 → 566
      DLP_2; Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins
      cl21457
      Location:96 → 212
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1KPV0.1

    Gene LinkOut

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