CAM4 calmodulin 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CAM4
Official Full Name: calmodulin 4
Primary source: TAIR:AT1G66410
Locus tag: AT1G66410
See related: Araport:AT1G66410
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACAM-4; calmodulin 4; CALMODULIN 4; T27F4.1; T27F4_1
Summary: encodes a calmodulin
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Genomic context

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See CAM4 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 2

Sequence:: Chromosome: 1; NC_003070.9 (24774113..24775984, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Co-immunoprecipitation assays confirmed the interaction of AtCaM4 with PATL1 in vivo and a phenotype analysis showed that patl1 mutant plants exhibited enhanced freezing tolerance. Thus, we conclude that AtCaM4 negatively regulates freezing tolerance in Arabidopsis by interacting with the novel CaM-binding protein PATL1.
Title: AtCaM4 interacts with a Sec14-like protein, PATL1, to regulate freezing tolerance in Arabidopsis in a CBF-independent manner.
Calmodulin 4 acts as a molecular link between RPK1 and RbohF.
Title: The Protein Trio RPK1-CaM4-RbohF Mediates Transient Superoxide Production to Trigger Age-Dependent Cell Death in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001198401.1

Supported by ESTs:

NM_001334237.1

Supported by ESTs:

NM_001334238.1

Supported by ESTs:

NM_105312.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: calmodulin 4

NP_001185330.1

calmodulin 4 (CAM4); CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 1 (TAIR:AT5G37780.1).

NP_176814.1

calmodulin 4 (CAM4); FUNCTIONS IN: calcium ion binding, signal transducer activity; INVOLVED IN: calcium-mediated signaling; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 1 (TAIR:AT5G37780.1); Has 33649 Blast hits to 23222 proteins in 1766 species: Archae - 3; Bacteria - 253; Metazoa - 14425; Fungi - 6839; Plants - 7076; Viruses - 0; Other Eukaryotes - 5053 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

24774113..24775984 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_105312.4 → NP_176814.1 calmodulin 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176814.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P0DH95, P0DH96, P25854, Q03510, Q9FJ05

UniProtKB/TrEMBL

A0A178WBP5, A0A5S9WQ45, A8Y7S8

Conserved Domains (1) summary

PTZ00184
Location:1 → 149

PTZ00184; calmodulin; Provisional
NM_001334237.1 → NP_001320584.1 calmodulin 4 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8ANC4

Conserved Domains (1) summary

PTZ00184
Location:1 → 113

PTZ00184; calmodulin; Provisional
NM_001334238.1 → NP_001320585.1 calmodulin 4 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8ANC4

Conserved Domains (1) summary

PTZ00184
Location:1 → 113

PTZ00184; calmodulin; Provisional
NM_001198401.1 → NP_001185330.1 calmodulin 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001185330.1

Status: REVIEWED

UniProtKB/TrEMBL

A8Y7S8, F4IEU4

Conserved Domains (2) summary

PTZ00184
Location:1 → 159

PTZ00184; calmodulin; Provisional

cd00051
Location:95 → 157

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...