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    Clathrin, heavy chain [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820284, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Clathrin, heavy chain
    Primary source
    TAIR:AT3G11130
    Locus tag
    AT3G11130
    See related
    Araport:AT3G11130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtCHC1; CHC1; clathrin heavy chain 1; F11B9.30
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    30
    Sequence:
    Chromosome: 3; NC_003074.8 (3482149..3492065, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene Ribosomal protein L41 family Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New ABA-hypersensitive Arabidopsis mutants are affected in loci mediating responses to water deficit and Dickeya dadantii infection. Plessis A, et al. PLoS One, 2011. PMID 21633512, Free PMC Article
    2. Clathrin mediates endocytosis and polar distribution of PIN auxin transporters in Arabidopsis. Kitakura S, et al. Plant Cell, 2011 May. PMID 21551390, Free PMC Article
    3. New Gateway-compatible vectors for a high-throughput protein-protein interaction analysis by a bimolecular fluorescence complementation (BiFC) assay in plants and their application to a plant clathrin structure analysis. Nishimura K, et al. Biosci Biotechnol Biochem, 2015. PMID 26193449
    4. Clathrin Heavy Chain Subunits Coordinate Endo- and Exocytic Traffic and Affect Stomatal Movement. Larson ER, et al. Plant Physiol, 2017 Oct. PMID 28830938, Free PMC Article
    5. Adaptor protein complex 2-mediated endocytosis is crucial for male reproductive organ development in Arabidopsis. Kim SY, et al. Plant Cell, 2013 Aug. PMID 23975898, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Secretion and endocytosis at the plasma membrane are sensitive to CHC1 and CHC2 function in seedling roots and that chc mutants have physiological defects in stomatal function and plant growth
      Title: Clathrin Heavy Chain Subunits Coordinate Endo- and Exocytic Traffic and Affect Stomatal Movement.
    2. Data indicate that MTV1 (AT3G16270) and AGD5 (AT5G54310) Physically Interact with clathrin.
      Title: MTV1 and MTV4 encode plant-specific ENTH and ARF GAP proteins that mediate clathrin-dependent trafficking of vacuolar cargo from the trans-Golgi network.
    3. study presents a genetic characterization of the role of clathrin in endocytosis and auxin-mediated plant development; data demonstrate a fundamental role for clathrin function in cell polarity, growth, patterning, and organogenesis
      Title: Clathrin mediates endocytosis and polar distribution of PIN auxin transporters in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111950.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables clathrin light chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    part_of clathrin coat of coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin coat of trans-Golgi network vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Clathrin, heavy chain
    NP_187724.2
    • Clathrin, heavy chain; FUNCTIONS IN: structural molecule activity, binding; INVOLVED IN: intracellular protein transport, vesicle-mediated transport; LOCATED IN: plasma membrane, vacuole; EXPRESSED IN: male gametophyte, guard cell, cultured cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Clathrin, heavy chain (InterPro:IPR016341), Clathrin, heavy chain, linker/propeller domain (InterPro:IPR016025), Tetratricopeptide-like helical (InterPro:IPR011990), Clathrin, heavy chain, propeller, N-terminal (InterPro:IPR001473), Clathrin, heavy chain, linker, core motif (InterPro:IPR015348), Clathrin, heavy chain, propeller repeat (InterPro:IPR022365), Armadillo-type fold (InterPro:IPR016024), Clathrin, heavy chain/VPS, 7-fold repeat (InterPro:IPR000547); BEST Arabidopsis thaliana protein match is: Clathrin, heavy chain (TAIR:AT3G08530.1); Has 1621 Blast hits to 1503 proteins in 495 species: Archae - 0; Bacteria - 35; Metazoa - 935; Fungi - 178; Plants - 133; Viruses - 0; Other Eukaryotes - 340 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3482149..3492065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111950.3 → NP_187724.2  Clathrin, heavy chain [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187724.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WM81, Q0WNJ6, Q9SRM1
      UniProtKB/TrEMBL
      A0A178V904, A0A5S9XCD9, A0A654FB98
      Conserved Domains (5) summary
      smart00299
      Location:1288 → 1430
      CLH; Clathrin heavy chain repeat homology
      pfam00637
      Location:1437 → 1575
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:20 → 56
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:344 → 367
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:369 → 434
      Clathrin_H_link; Clathrin-H-link
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WNJ6.1

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