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    UVI4 uv-b-insensitive 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818827, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UVI4
    Official Full Name
    uv-b-insensitive 4
    Primary source
    TAIR:AT2G42260
    Locus tag
    AT2G42260
    See related
    Araport:AT2G42260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    POLYCHOME; PYM; T24P15.17; T24P15_17; UV-B-INSENSITIVE 4
    Summary
    Encodes a novel plant-specific protein of unknown function. The UVI4 gene is expressed mainly in actively dividing cells. The hypocotyl cells in mutant seedlings undergo one extra round of endoreduplication. The uvi4 mutation also promoted the progression of endo-reduplication during leaf development.
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    Genomic context

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    See UVI4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (17601872..17603705, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene ncRNA Neighboring gene cytochrome P450, family 712, subfamily A, polypeptide 1 Neighboring gene U5 small nuclear ribonucleoprotein helicase Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutation in the uvi4 gene promotes progression of endo-reduplication and confers increased tolerance towards ultraviolet B light. Hase Y, et al. Plant J, 2006 Apr. PMID 16623893
    2. UBIQUITIN-SPECIFIC PROTEASE14 Interacts with ULTRAVIOLET-B INSENSITIVE4 to Regulate Endoreduplication and Cell and Organ Growth in Arabidopsis. Xu Y, et al. Plant Cell, 2016 May. PMID 27099260, Free PMC Article
    3. Perturbation of cell cycle regulation triggers plant immune response via activation of disease resistance genes. Bao Z, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23345424, Free PMC Article
    4. Roles of GIG1 and UVI4 in genome duplication in Arabidopsis thaliana. Iwata E, et al. Plant Signal Behav, 2012 Sep 1. PMID 22899078, Free PMC Article
    5. Trichome cell growth in Arabidopsis thaliana can be derepressed by mutations in at least five genes. Perazza D, et al. Genetics, 1999 May. PMID 10224275, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBIQUITIN-SPECIFIC PROTEASE14 Interacts with ULTRAVIOLET-B INSENSITIVE4 to Regulate Endoreduplication and Cell and Organ Growth in Arabidopsis
      Title: UBIQUITIN-SPECIFIC PROTEASE14 Interacts with ULTRAVIOLET-B INSENSITIVE4 to Regulate Endoreduplication and Cell and Organ Growth in Arabidopsis.
    2. CPR5 has a large role in cell cycle regulation and this role has a complex interaction with that of UVI4 and OSD1.
      Title: Interaction of CPR5 with cell cycle regulators UVI4 and OSD1 in Arabidopsis.
    3. These findings suggest that endomitosis and endoreplication are regulated by similar molecular mechanisms, in which two related proteins, GIG1 and UVI4, may inhibit APC/C in different ways.
      Title: Roles of GIG1 and UVI4 in genome duplication in Arabidopsis thaliana.
    4. UVI4 inhibits premature cell differentiation.
      Title: Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome.
    5. GIGAS CELL1 (GIG1)/OMISSION OF SECOND DIVISION1 (OSD1) and UVI4 encode novel plant-specific inhibitors of the anaphase-promoting complex/cyclosome ubiquitin ligase.
      Title: GIGAS CELL1, a novel negative regulator of the anaphase-promoting complex/cyclosome, is required for proper mitotic progression and cell fate determination in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001336961.1
    NM_129788.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosperm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in megagametogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nuclear division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to UV-B IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome branching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    uv-b-insensitive 4
    NP_181755.1
    • UV-B-INSENSITIVE 4 (UVI4); BEST Arabidopsis thaliana protein match is: UV-B-insensitive 4-like (TAIR:AT3G57860.1); Has 62 Blast hits to 62 proteins in 12 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 50; Viruses - 0; Other Eukaryotes - 12 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17601872..17603705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129788.3 → NP_181755.1  uv-b-insensitive 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181755.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48533
      UniProtKB/TrEMBL
      A0A654F6F0

    2. NM_001336961.1 → NP_001324441.1  uv-b-insensitive 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48533
      UniProtKB/TrEMBL
      A0A654F6F0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O48533.1

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