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    CG8067 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36552, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8067provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033891
    Locus tag
    Dmel_CG8067
    See related
    AllianceGenome:FB:FBgn0033891
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8067
    Summary
    Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in matrix side of mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; larval muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 16. Orthologous to human NDUFAF5 (NADH:ubiquinone oxidoreductase complex assembly factor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8067 in Genome Data Viewer
    Location:
    50C23-50C23; 2-68 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13983395..13984893)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9870900..9872398)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Chromosome transmission fidelity 4 Neighboring gene Related to the N terminus of tre oncogene Neighboring gene mastermind Neighboring gene mir-4978 stem loop Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. Vinci G, et al. PLoS One, 2008 Aug 6. PMID 18682733, Free PMC Article
    2. Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC). Borrás T, et al. Genetics, 2003 Feb. PMID 12618402, Free PMC Article
    3. Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Ni JQ, et al. Nat Methods, 2008 Jan. PMID 18084299, Free PMC Article
    4. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235
    5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in matrix side of mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8067-PA
    CG8067-PB
    NP_001260960.1
    NP_610922.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13983395..13984893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274031.2 → NP_001260960.1  uncharacterized protein Dmel_CG8067, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260960.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1S1
      Conserved Domains (2) summary
      TIGR02072
      Location:58 → 296
      BioC; malonyl-acyl carrier protein O-methyltransferase BioC
      pfam08241
      Location:79 → 170
      Methyltransf_11; Methyltransferase domain

    2. NM_137078.4 → NP_610922.1  uncharacterized protein Dmel_CG8067, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610922.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1S1
      Related
      FBpp0086721
      Conserved Domains (2) summary
      TIGR02072
      Location:58 → 296
      BioC; malonyl-acyl carrier protein O-methyltransferase BioC
      pfam08241
      Location:79 → 170
      Methyltransf_11; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K1S1 Q7K1S1

    Gene LinkOut

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