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    mdy midway [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44887, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mdyprovided by FlyBase
    Official Full Name
    midwayprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004797
    Locus tag
    Dmel_CG31991
    See related
    AllianceGenome:FB:FBgn0004797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13273; CG17937; CG17938; CG31991; CT39962; DGAT; Dgat1; DGAT1; DmDGAT1; Dmel\CG31991; mdcds_3562; Mdy
    Summary
    Enables diacylglycerol O-acyltransferase activity. Involved in negative regulation of lipid storage and regulation of nurse cell apoptotic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; larval muscle cell; and larval muscle system. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mdy in Genome Data Viewer
    Location:
    36B1-36B2; 2-53 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16816660..16826964)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16816660..16826964)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 37 member D1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chromosome segregation 1 Neighboring gene Aspartyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion. Long M, et al. EMBO J, 2022 May 16. PMID 35411952, Free PMC Article
    2. Fat-body brummer lipase determines survival and cardiac function during starvation in Drosophila melanogaster. Blumrich A, et al. iScience, 2021 Apr 23. PMID 33889813, Free PMC Article
    3. A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics. Tschapalda K, et al. EBioMedicine, 2016 Jun. PMID 27428418, Free PMC Article
    4. Adipose triglyceride lipase promotes prostaglandin-dependent actin remodeling by regulating substrate release from lipid droplets. Giedt MS, et al. Development, 2023 Oct 15. PMID 37306387, Free PMC Article
    5. Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A. Marchesin V, et al. Cell Rep, 2019 Dec 24. PMID 31875549, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Encodes a diacylglycerol O-acyltransferase; Mutations disrupt normal egg chamber development
      Title: Mutations in the midway gene disrupt a Drosophila acyl coenzyme A: diacylglycerol acyltransferase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables diacylglycerol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diacylglycerol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diacylglycerol O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of lipid storage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oogenesis HMP PubMed 
    involved_in regulation of nurse cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    midway
    Names
    CG31991-PA
    CG31991-PB
    CG31991-PC
    CG31991-PE
    diacylglycerol acyltransferase
    mdy-PA
    mdy-PB
    mdy-PC
    mdy-PE
    NP_609813.1
    NP_724016.1
    NP_724017.1
    NP_995724.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16816660..16826964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165195.3 → NP_724017.1  midway, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KT52, Q8ST50, Q960U8
      Related
      FBpp0080474
      Conserved Domains (1) summary
      cl00738
      Location:115 → 545
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    2. NM_135969.4 → NP_609813.1  midway, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609813.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KT52, Q8ST50, Q960U8
      Related
      FBpp0080472
      Conserved Domains (1) summary
      cl00738
      Location:115 → 545
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    3. NM_165194.3 → NP_724016.1  midway, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724016.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KT52, Q8ST50, Q960U8
      Related
      FBpp0080473
      Conserved Domains (1) summary
      cl00738
      Location:115 → 545
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    4. NM_206002.2 → NP_995724.2  midway, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KT52, Q8ST50, Q960U8
      Conserved Domains (1) summary
      cl00738
      Location:115 → 545
      MBOAT; MBOAT, membrane-bound O-acyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8ST50 Q8ST50
    Q960U8 Q960U8

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