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    Rnb R and B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43513, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnbprovided by FlyBase
    Official Full Name
    R and Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039696
    Locus tag
    Dmel_CG7837
    See related
    AllianceGenome:FB:FBgn0039696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7837; Dmel\CG7837
    Summary
    Involved in regulation of circadian rhythm. Located in cytosol. Is expressed in adult brain cell body rind. Human ortholog(s) of this gene implicated in ACTH-independent macronodular adrenal hyperplasia 2. Orthologous to human ARMC5 (armadillo repeat containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rnb in Genome Data Viewer
    Location:
    99C1-99C1; 3-99 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29795697..29799354, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25621419..25625076, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene kayak Neighboring gene long non-coding RNA:CR46110 Neighboring gene fos intronic gene Neighboring gene shroud Neighboring gene Death related ICE-like caspase Neighboring gene Electron transfer flavoprotein beta subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Screening of UNF Targets Identifies Rnb, a Novel Regulator of Drosophila Circadian Rhythms. Kozlov A, et al. J Neurosci, 2017 Jul 12. PMID 28592698, Free PMC Article
    2. Wnt pathway activation increases hypoxia tolerance during development. Gersten M, et al. PLoS One, 2014. PMID 25093834, Free PMC Article
    3. DRONC coordinates cell death and compensatory proliferation. Kondo S, et al. Mol Cell Biol, 2006 Oct. PMID 16980627, Free PMC Article
    4. The tobacco phosphatidylethanolamine-binding protein NtFT4 increases the lifespan of Drosophila melanogaster by interacting with the proteostasis network. Känel P, et al. Aging (Albany NY), 2022 Apr 8. PMID 35396341, Free PMC Article
    5. Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Lye CM, et al. Development, 2014 Oct. PMID 25294944, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of circadian rhythm IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    R and B
    Names
    CG7837-PA
    Rnb-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29795697..29799354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143469.2 → NP_651726.1  R and B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651726.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAH2
      Related
      FBpp0084903
      Conserved Domains (3) summary
      smart00225
      Location:801 → 904
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd00020
      Location:44 → 147
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:49 → 78
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAH2 Q9VAH2

    Gene LinkOut

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