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    Txl Thioredoxin-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Txlprovided by FlyBase
    Official Full Name
    Thioredoxin-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035631
    Locus tag
    Dmel_CG5495
    See related
    AllianceGenome:FB:FBgn0035631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5495; anon-WO0118547.248; CG5495; Dmel\CG5495; txl
    Summary
    Predicted to enable protein-disulfide reductase activity. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human TXNL1 (thioredoxin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Txl in Genome Data Viewer
    Location:
    64E6-64E7; 3-15 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5765846..5767084)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5758946..5760184)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA:CR43603 Neighboring gene antisense RNA:CR45831 Neighboring gene Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase Neighboring gene scrawny

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic structure and chromosomal localization of human thioredoxin-like protein gene (txl). Miranda-Vizuete A, et al. DNA Seq, 2000. PMID 10826702
    2. The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidases. Maiorino M, et al. J Mol Biol, 2007 Jan 26. PMID 17098255
    3. Genomic differentiation between temperate and tropical Australian populations of Drosophila melanogaster. Kolaczkowski B, et al. Genetics, 2011 Jan. PMID 21059887, Free PMC Article
    4. Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-Linked TDP-43 in Drosophila. Uechi H, et al. Mol Cell Biol, 2018 Feb 1. PMID 29109084, Free PMC Article
    5. Thioredoxin-2 affects lifespan and oxidative stress in Drosophila. Svensson MJ, et al. Hereditas, 2007 Mar. PMID 17567437

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. e catalytic mechanism of DmGPx, unlike that of selenocysteine (Sec)GPxs, involves formation of an internal disulfide that is pivotal to the interaction with Trx
      Title: The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-disulfide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Thioredoxin-like
    Names
    CG5495-PA
    Txl-PA
    thioredoxin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5765846..5767084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079214.4 → NP_523938.2  Thioredoxin-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523938.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMR7, Q9VRP3
      Related
      FBpp0076804
      Conserved Domains (2) summary
      cd02947
      Location:10 → 103
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      pfam06201
      Location:125 → 266
      PITH; PITH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KMR7 Q7KMR7
    Q9VRP3 Q9VRP3

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