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    Cpsf100 Cleavage and polyadenylation specificity factor 100 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43426, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cpsf100provided by FlyBase
    Official Full Name
    Cleavage and polyadenylation specificity factor 100provided by FlyBase
    Primary source
    FLYBASE:FBgn0027873
    Locus tag
    Dmel_CG1957
    See related
    AllianceGenome:FB:FBgn0027873
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD14168; CG1957; CPSF-100; CPSF100; Dmel\CG1957
    Summary
    Predicted to enable RNA binding activity. Involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway and mRNA 3'-end processing by stem-loop binding activity and cleavage. Part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human CPSF2 (cleavage and polyadenylation specific factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cpsf100 in Genome Data Viewer
    Location:
    98F5-98F5; 3-97 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29034573..29037062)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24860295..24862784)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45044 Neighboring gene beta1,4-N-acetylgalactosaminyltransferase B Neighboring gene Strictosidine synthase-like 2 Neighboring gene Slu7 Neighboring gene Protein C kinase 98E Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo characterization of the Drosophila mRNA 3' end processing core cleavage complex. Michalski D, et al. RNA, 2015 Aug. PMID 26081560, Free PMC Article
    2. Drosophila melanogaster retrotransposon and inverted repeat-derived endogenous siRNAs are differentially processed in distinct cellular locations. Harrington AW, et al. BMC Genomics, 2017 Apr 17. PMID 28415970, Free PMC Article
    3. Protein composition of catalytically active U7-dependent processing complexes assembled on histone pre-mRNA containing biotin and a photo-cleavable linker. Skrajna A, et al. Nucleic Acids Res, 2018 May 18. PMID 29529248, Free PMC Article
    4. TREX-2-ORC Complex of D. melanogaster Participates in Nuclear Export of Histone mRNA. Kurshakova MM, et al. Dokl Biochem Biophys, 2024 Feb. PMID 38189888, Free PMC Article
    5. A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs. Sullivan KD, et al. Mol Cell, 2009 May 15. PMID 19450530, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cleavage and polyadenylation specificity factor 100
    Names
    CG1957-PA
    Cpsf100-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29034573..29037062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143401.3 → NP_651658.1  cleavage and polyadenylation specificity factor 100 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651658.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IML7, Q9V3D6
      Related
      FBpp0084726
      Conserved Domains (5) summary
      smart01027
      Location:243 → 369
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:19 → 400
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:538 → 577
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      pfam13299
      Location:617 → 753
      CPSF100_C; Cleavage and polyadenylation factor 2 C-terminal
      cd16293
      Location:7 → 204
      CPSF2-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 2 and related proteins; MBL-fold metallo-hydrolase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3D6.1 Q9V3D6

    Gene LinkOut

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