Prosbeta5 Proteasome beta5 subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prosbeta5provided by FlyBase
Official Full Name: Proteasome beta5 subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0029134
Locus tag: Dmel_CG12323
See related: AllianceGenome:FB:FBgn0029134
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.116; Beta 5 subunit; beta-5; Beta-5; beta5; CG12323; dbeta5; Dmel\CG12323; LD08717; Pros b5; prosbeta5; PSMB5
Summary: Predicted to enable endopeptidase activity. Involved in centrosome cycle and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleoplasm. Part of proteasome core complex. Is expressed in adult head; adult heart; and organism. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 1. Orthologous to several human genes including PSMB5 (proteasome 20S subunit beta 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 47C1-47C1; 2-63 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (10819978..10821178)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (6707483..6708683)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteasome beta5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster.
Title: Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activity	IC Inferred by Curator more info	PubMed
enables endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables threonine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, beta-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proteasome beta5 subunit

Names: 20S proteasome; CG12323-PA; CG12323-PB; Prosbeta5-PA; Prosbeta5-PB; beta5

NP_652014.1

EC 3.4.25.-

NP_724974.1

EC 3.4.25.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

10819978..10821178

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143757.4 → NP_652014.1 proteasome beta5 subunit, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_652014.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K148, Q9NHX7

Related

FBpp0087320

Conserved Domains (2) summary

PTZ00488
Location:38 → 272

PTZ00488; Proteasome subunit beta type-5; Provisional

cd03761
Location:74 → 261

proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
NM_165801.2 → NP_724974.1 proteasome beta5 subunit, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724974.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K148, Q9NHX7

Related

FBpp0087319

Conserved Domains (2) summary

PTZ00488
Location:38 → 272

PTZ00488; Proteasome subunit beta type-5; Provisional

cd03761
Location:74 → 261

proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...