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    Naam Nicotinamide amidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42348, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naamprovided by FlyBase
    Official Full Name
    Nicotinamide amidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051216
    Locus tag
    Dmel_CG31216
    See related
    AllianceGenome:FB:FBgn0051216
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAM52663; anon-WO0172774.59; anon-WO0172774.60; CG31216; CG7444; CG7500; D-NAAM; Dmel\CG31216; dNaam
    Summary
    Enables nicotinamidase activity. Involved in determination of adult lifespan; negative regulation of neuron apoptotic process; and response to oxidative stress. Is expressed in several structures, including embryonic head sensory system; scolopale cell; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Naam in Genome Data Viewer
    Location:
    92A13-92B1; 3-66 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19671450..19698742)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15497172..15524464)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Valine-CAC 2-5 Neighboring gene ora transientless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutamate-gated chloride channel subunit alpha Neighboring gene long non-coding RNA:CR43488

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tripeptide IRW Upregulates NAMPT Protein Levels in Cells and Obese C57BL/6J Mice. Bhullar KS, et al. J Agric Food Chem, 2021 Feb 10. PMID 33522796
    2. Life span extension and neuronal cell protection by Drosophila nicotinamidase. Balan V, et al. J Biol Chem, 2008 Oct 10. PMID 18678867, Free PMC Article
    3. Reconstructing eukaryotic NAD metabolism. Rongvaux A, et al. Bioessays, 2003 Jul. PMID 12815723
    4. The NAD(+) precursor NMN activates dSarm to trigger axon degeneration in Drosophila. Llobet Rosell A, et al. Elife, 2022 Dec 23. PMID 36476387, Free PMC Article
    5. An insecticide target in mechanoreceptor neurons. Qiao X, et al. Sci Adv, 2022 Nov 25. PMID 36417522, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinamidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD salvage TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nicotinamide amidase
    Names
    CG31216-PA
    CG31216-PB
    Naam-PA
    Naam-PB
    nicotinamidase
    NP_001262738.1
    NP_732446.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19671450..19698742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169872.2 → NP_732446.1  nicotinamide amidase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732446.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDU7
      Related
      FBpp0083200
      Conserved Domains (3) summary
      cd00051
      Location:20 → 81
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd01011
      Location:97 → 315
      nicotinamidase; Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is ...
      pfam13499
      Location:21 → 82
      EF-hand_7; EF-hand domain pair

    2. NM_001275809.1 → NP_001262738.1  nicotinamide amidase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262738.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDU7
      Conserved Domains (3) summary
      cd00051
      Location:20 → 81
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd01011
      Location:97 → 315
      nicotinamidase; Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is ...
      pfam13499
      Location:21 → 82
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDU7 Q9VDU7

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