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    sl small wing [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32601, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slprovided by FlyBase
    Official Full Name
    small wingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003416
    Locus tag
    Dmel_CG4200
    See related
    AllianceGenome:FB:FBgn0003416
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4200; Dmel\CG4200; DPLCgamma; p145; PLC; plc-gamma; PLC-gamma; PLC-gamma D; plc-gammad; PLC-gammaD; Plcgamma; PLCgamma; PLCgamma1; PLCgammaDmel; Sl
    Summary
    Predicted to enable phosphatidylinositol phospholipase C activity. Involved in several processes, including border follicle cell migration; negative regulation of crystal cell differentiation; and negative regulation of signal transduction. Predicted to be active in ruffle membrane. Is expressed in anterior midgut primordium; endoderm; posterior midgut primordium; and spermatozoon. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 3; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to several human genes including PLCG2 (phospholipase C gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    14B15-14B17; 1-53 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16350315..16356482)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16244348..16250515)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dorsal switch protein 1 Neighboring gene U2 small nuclear riboprotein auxiliary factor 50 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class Q

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deficiency and Duplications for the Gene Bobbed in Drosophila Melanogaster. Sivertzev-Dobzhansky NP, et al. Genetics, 1933 May. PMID 17246687, Free PMC Article
    2. Drosophila phospholipase C-gamma expressed predominantly in blastoderm cells at cellularization and in endodermal cells during later embryonic stages. Emori Y, et al. J Biol Chem, 1994 Jul 29. PMID 8034716
    3. Distinct phospholipase C-gamma-dependent signaling pathways in the Drosophila eye and wing are revealed by a new small wing allele. Mankidy R, et al. Genetics, 2003 Jun. PMID 12807776, Free PMC Article
    4. Phospholipase C-gamma contains introns shared by src homology 2 domains in many unrelated proteins. Manning CM, et al. Genetics, 2003 Jun. PMID 12807765, Free PMC Article
    5. Drosophila Plc21C is involved in calcium wave propagation during egg activation. Hu Q, et al. MicroPubl Biol, 2020 Apr 1. PMID 32550503, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The phospholipase C-gamma (PLC-gamma) encoded by small wing (sl) acts as such a link between growth and patterning/differentiation by modulating some MAPK outputs once activated by the insulin pathway.
      Title: Insulin receptor-mediated signaling via phospholipase C-γ regulates growth and differentiation in Drosophila.
    2. Sl PLC gamma is required for endoplasmic reticulum retention of cleaved spi during eye development.
      Title: Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila.
    3. Sl has a role in wing and eye development through receptor tyrosine kinase signaling
      Title: Distinct phospholipase C-gamma-dependent signaling pathways in the Drosophila eye and wing are revealed by a new small wing allele.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in border follicle cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of R7 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of crystal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of sevenless signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to insulin IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small wing
    Names
    CG4200-PA
    phospholipase C gamma
    phospholipase cgamma
    sl-PA
    NP_476726.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16350315..16356482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057378.3 → NP_476726.2  small wing [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476726.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24284, Q9VXH3
      Related
      FBpp0074009
      Conserved Domains (7) summary
      smart00149
      Location:981 → 1091
      PLCYc; Phospholipase C, catalytic domain (part); domain Y
      cd00275
      Location:1109 → 1215
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08592
      Location:323 → 470
      PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
      cd09932
      Location:696 → 796
      SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
      cd10341
      Location:584 → 682
      SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
      cd11825
      Location:828 → 880
      SH3_PLCgamma; Src homology 3 domain of Phospholipase C (PLC) gamma
      cd13362
      Location:22 → 147
      PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24284 Q24284
    Q8MQR1 Q8MQR1
    Q9VXH3 Q9VXH3

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