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    Coprox Coproporphyrinogen oxidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44701, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Coproxprovided by FlyBase
    Official Full Name
    Coproporphyrinogen oxidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0021944
    Locus tag
    Dmel_CG3433
    See related
    AllianceGenome:FB:FBgn0021944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM14838; CG3433; Dmel\CG3433; l(2)k10617; l(2)k11018
    Summary
    Predicted to enable coproporphyrinogen oxidase activity and protein homodimerization activity. Predicted to be involved in protoporphyrinogen IX biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Coprox in Genome Data Viewer
    Location:
    27C7-27C7; 2-23 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6964421..6965887)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6964421..6965887)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ada2a-containing complex component 1 Neighboring gene 3-Hydroxymethyl-3-methylglutaryl-CoA lyase Neighboring gene septin interacting protein 2 Neighboring gene Small ubiquitin like modifier Neighboring gene small ribonucleoprotein particle U1 subunit 70K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spatial and temporal control of gene manipulation in Drosophila via drug-activated Cas9 nucleases. Huynh N, et al. Insect Biochem Mol Biol, 2020 May. PMID 32105778
    2. A Drosophila CRISPR/Cas9 Toolkit for Conditionally Manipulating Gene Expression in the Prothoracic Gland as a Test Case for Polytene Tissues. Huynh N, et al. G3 (Bethesda), 2018 Nov 6. PMID 30213867, Free PMC Article
    3. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article
    4. Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. Wang ZA, et al. Nat Commun, 2012 Apr 3. PMID 22473013, Free PMC Article
    5. Identification of transcriptional responsive genes to acetic acid, ethanol, and 2-phenylethanol exposure in Drosophila melanogaster. Seong KM, et al. Pestic Biochem Physiol, 2020 May. PMID 32359537

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables coproporphyrinogen oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables coproporphyrinogen oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coproporphyrinogen oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    coproporphyrinogen oxidase
    Names
    CG3433-PA
    CG3433-PB
    Coprox-PA
    Coprox-PB
    corpoporphyrinogen III oxidase
    NP_001285697.1
    NP_524777.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6964421..6965887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298768.1 → NP_001285697.1  coproporphyrinogen oxidase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285697.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3D2
      UniProtKB/TrEMBL
      X2J9R2
      Conserved Domains (1) summary
      pfam01218
      Location:88 → 390
      Coprogen_oxidas; Coproporphyrinogen III oxidase

    2. NM_080038.4 → NP_524777.1  coproporphyrinogen oxidase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524777.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3D2
      UniProtKB/TrEMBL
      X2J9R2
      Related
      FBpp0078980
      Conserved Domains (1) summary
      pfam01218
      Location:88 → 390
      Coprogen_oxidas; Coproporphyrinogen III oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3D2.1 Q9V3D2
    X2J9R2 X2J9R2

    Gene LinkOut

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