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    feo fascetto [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32015, updated on 9-Dec-2024

    Summary

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    Official Symbol
    feoprovided by FlyBase
    Official Full Name
    fascettoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030241
    Locus tag
    Dmel_CG11207
    See related
    AllianceGenome:FB:FBgn0030241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11207; Dmel\CG11207; EA86; Feo; Feo1; l(1)9Fe; l(1)BP1; PRC1; Q54
    Summary
    Predicted to enable microtubule binding activity. Involved in mitotic spindle organization. Located in cytosol and spindle midzone. Is expressed in several structures, including CNS glial cell; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See feo in Genome Data Viewer
    Location:
    9F5-9F5; 1-33 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10852446..10854869, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10746479..10748902, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene 6-phosphogluconolactonase Neighboring gene uncharacterized protein Neighboring gene sister of feo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Astral microtubule cross-linking safeguards uniform nuclear distribution in the Drosophila syncytium. Deshpande O, et al. J Cell Biol, 2022 Jan 3. PMID 34766978, Free PMC Article
    2. Recruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complex. D'Avino PP, et al. PLoS One, 2007 Jun 27. PMID 17593971, Free PMC Article
    3. Live Imaging and Analysis of Meiotic Cytokinesis in Drosophila Testes. Kunduri G, et al. Bio Protoc, 2024 Jan 20. PMID 38268980, Free PMC Article
    4. [Characteristics of inserted mutations obtained in the P-M hybrid dysgenesis system in the 9F12-10A7 region of the Drosophila melanogaster X-chromosome]. Pokholkova GV, et al. Genetika, 1989 Oct. PMID 2559870
    5. Neuronal necrosis is regulated by a conserved chromatin-modifying cascade. Liu K, et al. Proc Natl Acad Sci U S A, 2014 Sep 23. PMID 25201987, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRC1 binding to polycomb response elements is not strictly dependent on PRC2 and H3K27 methylation.
      Title: Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements.
    2. Feo may control organization, stability, and motor composition of antiparallel interpolar microtubules at midzone, thereby facilitating kinesin-5-driven sliding filament mechanism underlying proper anaphase B spindle elongation and chromosome segregation
      Title: The microtubule cross-linker Feo controls the midzone stability, motor composition, and elongation of the anaphase B spindle in Drosophila embryos.
    3. Data show that Sticky (Sti), tile ring component Citron kinase (CIT-K) interacts directly with two kinesins, Nebbish and Pavarotti and that in turn these kinesins interact with each other and with another central spindle protein, Fascetto.
      Title: Citron kinase controls a molecular network required for midbody formation in cytokinesis.
    4. Feo interacts with the plus ends of central spindle microtubules (MTs) so as to maintain their precise interdigitation during anaphase-telophase MT elongation and antiparallel sliding.
      Title: Feo, the Drosophila homolog of PRC1, is required for central-spindle formation and cytokinesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fascetto
    Names
    CG11207-PA
    fasecetto
    feo-PA
    lethal(1)9Fe

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10852446..10854869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132430.3 → NP_572658.2  fascetto [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572658.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZ62
      Related
      FBpp0073266
      Conserved Domains (1) summary
      pfam03999
      Location:39 → 613
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T9H6 Q8T9H6
    Q95SC3 Q95SC3
    Q9VZ62 Q9VZ62

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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