U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mtap Methylthioadenosine phosphorylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36955, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Mtapprovided by FlyBase
    Official Full Name
    Methylthioadenosine phosphorylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034215
    Locus tag
    Dmel_CG4802
    See related
    AllianceGenome:FB:FBgn0034215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4802; Dmel\CG4802; MTAP
    Summary
    Predicted to enable S-methyl-5-thioadenosine phosphorylase activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be active in cytosol. Is expressed in adult head; fat body primordium; and visceral mesoderm. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Mtap in Genome Data Viewer
    Location:
    54B7-54B7; 2-82 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17427795..17429315)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13315300..13316820)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene connector enhancer of ksr Neighboring gene lethal (2) k01209 Neighboring gene uncharacterized protein Neighboring gene Brahma associated protein 55kD Neighboring gene Lethal hybrid rescue Neighboring gene Egg-derived tyrosine phosphatase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Methylthioadenosine phosphorylase (MTAP) in hearing: gene disruption by chromosomal rearrangement in a hearing impaired individual and model organism analysis. Williamson RE, et al. Am J Med Genet A, 2007 Jul 15. PMID 17534888
    2. Unraveling the protective effect of a Drosophila phosphatidylethanolamine-binding protein upon bacterial infection by means of proteomics. Reumer A, et al. Dev Comp Immunol, 2009 Nov. PMID 19545586
    3. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
    4. Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. Orian A, et al. Genes Dev, 2003 May 1. PMID 12695332, Free PMC Article
    5. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables S-methyl-5-thioadenosine phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-methyl-5-thioadenosine phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    methylthioadenosine phosphorylase
    Names
    CG4802-PA
    CG4802-PB
    CG4802-PC
    Mtap-PA
    Mtap-PB
    Mtap-PC
    methylthioadenosine phosphorylase ortholog
    NP_001261049.1
    NP_001286525.1
    NP_611208.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17427795..17429315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299596.1 → NP_001286525.1  methylthioadenosine phosphorylase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286525.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V813
      UniProtKB/TrEMBL
      A0A0B4LFH0
      Conserved Domains (2) summary
      COG0005
      Location:12 → 264
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      cl00303
      Location:17 → 263
      PNP_UDP_1; Phosphorylase superfamily

    2. NM_137364.4 → NP_611208.1  methylthioadenosine phosphorylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611208.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V813
      UniProtKB/TrEMBL
      A0A0B4LFH0
      Related
      FBpp0086072
      Conserved Domains (2) summary
      COG0005
      Location:12 → 264
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      cl00303
      Location:17 → 263
      PNP_UDP_1; Phosphorylase superfamily

    3. NM_001274120.2 → NP_001261049.1  methylthioadenosine phosphorylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261049.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG54
      Conserved Domains (2) summary
      COG0005
      Location:12 → 264
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      cl00303
      Location:17 → 263
      PNP_UDP_1; Phosphorylase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG54 A0A0B4KG54
    A0A0B4LFH0 A0A0B4LFH0
    Q9V813.1 Q9V813

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous