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    mib2 mind bomb 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35170, updated on 27-Dec-2024

    Summary

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    Official Symbol
    mib2provided by FlyBase
    Official Full Name
    mind bomb 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0086442
    Locus tag
    Dmel_CG17492
    See related
    AllianceGenome:FB:FBgn0086442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Be; CG17492; D-mibl; Dmel\CG17492; i115; l(2)37Be; Mib-2; mib1/2; Mib2; suelto
    Summary
    Enables myosin II heavy chain binding activity and myosin II light chain binding activity. Involved in muscle cell cellular homeostasis and myoblast fusion. Located in M band and Z disc. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; head mesoderm; muscle cell; and trunk visceral muscle primordium. Orthologous to human MIB2 (MIB E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mib2 in Genome Data Viewer
    Location:
    37B10-37B11; 2-54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19034444..19041541)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19034444..19041541)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene similar to Deadpan Neighboring gene hook Neighboring gene uncharacterized protein Neighboring gene Catecholamines up Neighboring gene Tetratricopeptide repeat domain 19 Neighboring gene Acinus

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the essential protein domains for Mib2 function during the development of the Drosophila larval musculature and adult flight muscles. Domsch K, et al. PLoS One, 2017. PMID 28282454, Free PMC Article
    2. The catecholamines up (Catsup) protein of Drosophila melanogaster functions as a negative regulator of tyrosine hydroxylase activity. Stathakis DG, et al. Genetics, 1999 Sep. PMID 10471719, Free PMC Article
    3. Abba is an essential TRIM/RBCC protein to maintain the integrity of sarcomeric cytoarchitecture. Domsch K, et al. J Cell Sci, 2013 Aug 1. PMID 23729735
    4. Mind bomb 2 promotes cell migration and epithelial structure by regulating adhesion complexes and the actin cytoskeleton. Trivedi S, et al. Dev Biol, 2022 Nov. PMID 36067835
    5. Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy. Ribot C, et al. PLoS Genet, 2022 Jan. PMID 35025870, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mib2 plays an additional important role in the development of adult thorax muscles, particularly in maintaining the larval templates for the dorsal longitudinal indirect flight muscles during metamorphosis.
      Title: Identification of the essential protein domains for Mib2 function during the development of the Drosophila larval musculature and adult flight muscles.
    2. Mib2 acts sequentially in myoblast fusion and sarcomeric stability by two separable processes involving distinct functions of Mib2.
      Title: Mind bomb 2, a founder myoblast-specific protein, regulates myoblast fusion and muscle stability.
    3. These data suggest strongly that mib2 is involved in a novel Notch- and integrin-independent pathway that maintains the integrity of fully differentiated muscles and prevents their apoptotic degeneration.
      Title: Drosophila mind bomb2 is required for maintaining muscle integrity and survival.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables myosin II heavy chain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables myosin II light chain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mind bomb 2
    Names
    CG17492-PA
    CG17492-PB
    CG17492-PC
    Mib2
    lethal (2) 37Be
    mib2-PA
    mib2-PB
    mib2-PC
    mindbomb2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19034444..19041541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136089.3 → NP_609933.1  mind bomb 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ14
      Related
      FBpp0080686
      Conserved Domains (7) summary
      cd00204
      Location:464 → 582
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd02339
      Location:85 → 129
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      pfam06701
      Location:156 → 220
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:468 → 560
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:549 → 604
      Ank_5; Ankyrin repeats (many copies)
      pfam13920
      Location:1002 → 1044
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      sd00045
      Location:464 → 494
      ANK; ANK repeat [structural motif]

    2. NM_001273625.1 → NP_001260554.1  mind bomb 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260554.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ14
      Conserved Domains (7) summary
      cd00204
      Location:464 → 582
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd02339
      Location:85 → 129
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      pfam06701
      Location:156 → 220
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:468 → 560
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:549 → 604
      Ank_5; Ankyrin repeats (many copies)
      pfam13920
      Location:1002 → 1044
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      sd00045
      Location:464 → 494
      ANK; ANK repeat [structural motif]

    3. NM_001273626.1 → NP_001260555.1  mind bomb 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260555.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ14
      Conserved Domains (7) summary
      cd00204
      Location:464 → 582
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd02339
      Location:85 → 129
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      pfam06701
      Location:156 → 220
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:468 → 560
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:549 → 604
      Ank_5; Ankyrin repeats (many copies)
      pfam13920
      Location:1002 → 1044
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      sd00045
      Location:464 → 494
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ14 Q9VJ14

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