Klp68D Kinesin-like protein at 68D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Klp68Dprovided by FlyBase
Official Full Name: Kinesin-like protein at 68Dprovided by FlyBase
Primary source: FLYBASE:FBgn0004381
Locus tag: Dmel_CG7293
See related: AllianceGenome:FB:FBgn0004381
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7293; Dmel\CG7293; DmKlp68D; KIF 3B; KIF3B; KLP-5; Klp5; KLP5; klp68d; KLP68D; KLP68Ddm; KLP[[64D/68D]]
Summary: Enables cytoskeletal motor activity. Involved in anterograde axonal transport; establishment or maintenance of microtubule cytoskeleton polarity; and sensory perception of smell. Part of microtubule associated complex. Is expressed in several structures, including embryonic central brain neurons; female germline cell; ganglia; gonad; and sensory nervous system primordium. Used to study chromosome 16p11.2 deletion syndrome, 593-kb. Human ortholog(s) of this gene implicated in retinitis pigmentosa 89. Orthologous to several human genes including KIF3B (kinesin family member 3B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11795614..11798875)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11788714..11791975)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	IDA Inferred from Direct Assay more info	PubMed
enables cytoskeletal motor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in anterograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of microtubule cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based movement	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed

Names: CG7293-PA; CG7293-PB; Kinesin-2; Kinesin1; Klp68D-PA; Klp68D-PB; kinesin II

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