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    Grik grik [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42476, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grikprovided by FlyBase
    Official Full Name
    grikprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038840
    Locus tag
    Dmel_CG5621
    See related
    AllianceGenome:FB:FBgn0038840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0138359.5; CG5621; CT17756; DKaiRIC; DmelCG5621; Dmel\CG5621; KaiR1C
    Summary
    Predicted to enable kainate selective glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and regulation of synaptic activity. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in adult CNS glial cell; adult brain; adult head; and transmedullary neuron Tm5c. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Grik in Genome Data Viewer
    Location:
    93A2-93A3; 3-69 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20901956..20908263)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16727678..16733985)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44947 Neighboring gene Kctd12-like Neighboring gene ncRNA Neighboring gene Turandot X Neighboring gene antisense RNA:CR44106 Neighboring gene uncharacterized protein Neighboring gene hadley

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction. Featherstone DE, et al. J Neurosci, 2005 Mar 23. PMID 15788777, Free PMC Article
    2. Novel Functional Properties of Drosophila CNS Glutamate Receptors. Li Y, et al. Neuron, 2016 Dec 7. PMID 27889096, Free PMC Article
    3. A hard-wired glutamatergic circuit pools and relays UV signals to mediate spectral preference in Drosophila. Karuppudurai T, et al. Neuron, 2014 Feb 5. PMID 24507194, Free PMC Article
    4. Autocrine inhibition by a glutamate-gated chloride channel mediates presynaptic homeostatic depression. Li X, et al. Sci Adv, 2021 Dec 3. PMID 34851664, Free PMC Article
    5. Ih channels control feedback regulation from amacrine cells to photoreceptors. Hu W, et al. PLoS Biol, 2015 Apr. PMID 25831426, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kainate selective glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synaptic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    grik
    Names
    CG5621-PA
    CG5621-PC
    CG5621-PD
    Grik-PA
    Grik-PC
    Grik-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20901956..20908263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142670.3 → NP_650927.1  grik, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650927.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961Q6, Q9VDH2
      Related
      FBpp0083382
      Conserved Domains (4) summary
      cd06382
      Location:37 → 391
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      pfam00060
      Location:543 → 799
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:53 → 374
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:411 → 781
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    2. NM_001275859.1 → NP_001262788.1  grik, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262788.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ0
      Conserved Domains (4) summary
      cd06382
      Location:37 → 391
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      pfam00060
      Location:543 → 816
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:53 → 374
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:411 → 781
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    3. NM_001043270.2 → NP_001036735.2  grik, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036735.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI38
      Conserved Domains (4) summary
      cd06382
      Location:37 → 391
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      pfam00060
      Location:543 → 815
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:53 → 374
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:411 → 781
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHJ0 A0A0B4KHJ0
    Q0KI38 Q0KI38
    Q9VDH2 Q9VDH2

    Gene LinkOut

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