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    tous testes of unusual size [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37582, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tousprovided by FlyBase
    Official Full Name
    testes of unusual sizeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034745
    Locus tag
    Dmel_CG4329
    See related
    AllianceGenome:FB:FBgn0034745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.244; Cfap57; CG4329; Dmel\CG4329
    Summary
    Involved in flagellated sperm motility and sensory perception of sound. Is expressed in Johnston organ neurons and spermatozoon. Human ortholog(s) of this gene implicated in spermatogenic failure 95. Orthologous to human CFAP57 (cilia and flagella associated protein 57). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tous in Genome Data Viewer
    Location:
    58F2-58F2; 2-100 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22609334..22613376, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18496839..18500881, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S16 Neighboring gene Vacuolar protein sorting 20 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cyclin-dependent kinase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impact of cilia-related genes on mitochondrial dynamics during Drosophila spermatogenesis. Bauerly E, et al. Dev Biol, 2022 Feb. PMID 34822845
    2. salto/CG13164 is required for sperm head morphogenesis in Drosophila. Augière C, et al. Mol Biol Cell, 2019 Mar 1. PMID 30601696, Free PMC Article
    3. The dynamics of protein localisation to restricted zones within Drosophila mechanosensory cilia. Xiang W, et al. Sci Rep, 2022 Aug 3. PMID 35922464, Free PMC Article
    4. Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Baeg GH, et al. Genes Dev, 2005 Aug 15. PMID 16055650, Free PMC Article
    5. Structure and molecular basis of spermatid elongation in the Drosophila testis. Huang Q, et al. Open Biol, 2023 Nov. PMID 37935354, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    testes of unusual size
    Names
    CG4329-PA
    tous-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22609334..22613376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137843.3 → NP_611687.1  testes of unusual size [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611687.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U0T8, Q9W235
      Related
      FBpp0071851
      Conserved Domains (6) summary
      COG2319
      Location:328 → 667
      WD40; WD40 repeat [General function prediction only]
      pfam01442
      Location:701 → 864
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam07462
      Location:784 → 1011
      MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus
      pfam10211
      Location:958 → 1026
      Ax_dynein_light; Axonemal dynein light chain
      sd00039
      Location:338 → 383
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:384 → 668
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U0T8 Q5U0T8
    Q8IHA3 Q8IHA3
    Q8IHF3 Q8IHF3
    Q95SP7 Q95SP7
    Q9W235 Q9W235

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