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    Gasz gasz [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35795, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gaszprovided by FlyBase
    Official Full Name
    gaszprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033273
    Locus tag
    Dmel_CG2183
    See related
    AllianceGenome:FB:FBgn0033273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD05795; CG2183; dGasz; Dmel\CG2183; gasz; GASZ
    Summary
    Involved in primary piRNA processing. Is active in cytoplasmic side of mitochondrial outer membrane. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gasz in Genome Data Viewer
    Location:
    44B7-44B8; 2-58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8167948..8170089)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4055453..4057594)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Rs1 Neighboring gene uncharacterized protein Neighboring gene Mlh1 Neighboring gene LDL receptor protein 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Piwi Nuclear Localization and Its Regulatory Mechanism in Drosophila Ovarian Somatic Cells. Yashiro R, et al. Cell Rep, 2018 Jun 19. PMID 29925005
    2. Slicing and Binding by Ago3 or Aub Trigger Piwi-Bound piRNA Production by Distinct Mechanisms. Wang W, et al. Mol Cell, 2015 Sep 3. PMID 26340424, Free PMC Article
    3. Armitage determines Piwi-piRISC processing from precursor formation and quality control to inter-organelle translocation. Yamashiro H, et al. EMBO Rep, 2020 Feb 5. PMID 31833223, Free PMC Article
    4. Kc167, a widely used Drosophila cell line, contains an active primary piRNA pathway. Vrettos N, et al. RNA, 2017 Jan. PMID 27789612, Free PMC Article
    5. Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery. Munafò M, et al. Genes Dev, 2019 Jul 1. PMID 31123065, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in primary piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in primary piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic side of mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gasz
    Names
    CG2183-PA
    GASZ ortholog
    Gasz-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8167948..8170089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136518.4 → NP_610362.1  gasz [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610362.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K5K0
      Related
      FBpp0087866
      Conserved Domains (6) summary
      cd09487
      Location:273 → 321
      SAM_superfamily; SAM (Sterile alpha motif )
      smart00454
      Location:273 → 324
      SAM; Sterile alpha motif
      PHA03233
      Location:289 → 366
      PHA03233; DNA packaging protein UL32; Provisional
      cd00204
      Location:74 → 198
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:111 → 208
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:110 → 143
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K5K0 Q7K5K0

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