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    Uch Ubiquitin carboxy-terminal hydrolase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33397, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Uchprovided by FlyBase
    Official Full Name
    Ubiquitin carboxy-terminal hydrolaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010288
    Locus tag
    Dmel_CG4265
    See related
    AllianceGenome:FB:FBgn0010288
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg4265; CG4265; Dmel\CG4265; dUch; dUCH; P35122; UBL; uch; UCH; uch-D; Uch-D; UCH-D; UCH-D19; UCH-L1; Uchl; Uchl1; UCHL1
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in positive regulation of glycolytic process. Predicted to be active in cytoplasm. Is expressed in adult head; nurse cell; oocyte; organism; and spermatocyte. Used to study Parkinson's disease and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; hereditary spastic paraplegia 79A; and hereditary spastic paraplegia 79B. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1) and UCHL3 (ubiquitin C-terminal hydrolase L3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Uch in Genome Data Viewer
    Location:
    22D4-22D4; 2-5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2212738..2214211, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2212738..2214211, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene daedalus Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and analysis of expression of a ubiquitin carboxyl terminal hydrolase expressed during oogenesis in Drosophila melanogaster. Zhang N, et al. Dev Biol, 1993 May. PMID 7683284
    2. Evaluating Dose- and Time-Dependent Effects of Vitamin C Treatment on a Parkinson's Disease Fly Model. Man Anh H, et al. Parkinsons Dis, 2019. PMID 30719278, Free PMC Article
    3. Evaluating the Potential of Portulaca oleracea L. for Parkinson's Disease Treatment Using a Drosophila Model with dUCH-Knockdown. Truong HKT, et al. Parkinsons Dis, 2019. PMID 31143437, Free PMC Article
    4. Targeting UCH in Drosophila melanogaster as a model for Parkinson's disease. Thao DTP. Front Biosci (Landmark Ed), 2020 Jan 1. PMID 31585883
    5. High-level expression of active recombinant ubiquitin carboxyl-terminal hydrolase of Drosophila melanogaster in Pichia pastoris. Jin FL, et al. Protein Expr Purif, 2009 Jun. PMID 18817875, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crucial Roles of Ubiquitin Carboxy-Terminal Hydrolase L1 in Motor Neuronal Health by Drosophila Model.
      Title: Crucial Roles of Ubiquitin Carboxy-Terminal Hydrolase L1 in Motor Neuronal Health by Drosophila Model.
    2. Targeting UCH in Drosophila melanogaster as a model for Parkinson's disease.
      Title: Targeting UCH in Drosophila melanogaster as a model for Parkinson's disease.
    3. Results suggest that UCH knockdown in drosophila is a promising model for studying the pathogenesis and epidemiology of Parkinson's disease. It shows degeneration of dopaminergic neurons followed by a shortage of dopamine on the brain and locomotor dysfunction.
      Title: Drosophila Ubiquitin C-Terminal Hydrolase Knockdown Model of Parkinson's Disease.
    4. These results indicate that the overexpression of dUCH impairs R7 photoreceptor cell differentiation by down-regulating the MAPK pathway.
      Title: Overexpression of ubiquitin carboxyl terminal hydrolase impairs multiple pathways during eye development in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of glycolytic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxy-terminal hydrolase
    Names
    CG4265-PA
    CG4265-PB
    CG4265-PC
    Uch-PA
    Uch-PB
    Uch-PC
    ubiquitin C-terminal hydrolase
    ubiquitin carboxyl terminal hydrolase
    ubiquitin carboxyterminal hydrolase
    NP_001188681.1
    NP_001259915.1
    NP_476940.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2212738..2214211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057592.4 → NP_476940.1  ubiquitin carboxy-terminal hydrolase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476940.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35122, Q4PIX7, Q9TWA0, Q9V417
      UniProtKB/TrEMBL
      M9MRD0
      Related
      FBpp0077516
      Conserved Domains (1) summary
      cd09616
      Location:4 → 222
      Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

    2. NM_001272986.1 → NP_001259915.1  ubiquitin carboxy-terminal hydrolase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259915.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE40
      Conserved Domains (1) summary
      cd09616
      Location:4 → 219
      Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

    3. NM_001201752.2 → NP_001188681.1  ubiquitin carboxy-terminal hydrolase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188681.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35122, Q4PIX7, Q9TWA0, Q9V417
      UniProtKB/TrEMBL
      M9MRD0
      Conserved Domains (1) summary
      cd09616
      Location:4 → 222
      Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRD0 M9MRD0
    M9PE40 M9PE40
    P35122.2 P35122

    Gene LinkOut

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