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    MS2 methionine synthase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821147, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MS2
    Official Full Name
    methionine synthase 2
    Primary source
    TAIR:AT3G03780
    Locus tag
    AT3G03780
    See related
    Araport:AT3G03780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMS2; F20H23.19; F20H23_19; methionine synthase 2
    Summary
    Encodes a cytosolic methionine synthase, involved in methionine regeneration via the activated methyl cycle (or SAM cycle)
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    Genomic context

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    See MS2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (956862..961032)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene ankyrin repeat family protein / regulator of chromosome condensation (RCC1) family protein Neighboring gene syntaxin of plants 131 Neighboring gene O-fucosyltransferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Male Sterile2 encodes a plastid-localized fatty acyl carrier protein reductase required for pollen exine development in Arabidopsis. Chen W, et al. Plant Physiol, 2011 Oct. PMID 21813653, Free PMC Article
    2. METHIONINE SYNTHASE1 Is Involved in Chromatin Silencing by Maintaining DNA and Histone Methylation. Yan X, et al. Plant Physiol, 2019 Sep. PMID 31331996, Free PMC Article
    3. Methionine metabolism in plants: chloroplasts are autonomous for de novo methionine synthesis and can import S-adenosylmethionine from the cytosol. Ravanel S, et al. J Biol Chem, 2004 May 21. PMID 15024005
    4. Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis. Saracco SA, et al. Plant J, 2009 Jul. PMID 19292762, Free PMC Article
    5. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MS2-mediated conserved plastidial pathway for the production of fatty alcohols that are essential for pollen wall biosynthesis in Arabidopsis.
      Title: Male Sterile2 encodes a plastid-localized fatty acyl carrier protein reductase required for pollen exine development in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_001125092.1
    NM_111249.5
    NM_180176.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methionine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    methionine synthase 2
    NP_001118564.1
    • methionine synthase 2 (MS2); FUNCTIONS IN: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity, methionine synthase activity; INVOLVED IN: response to salt stress, methionine biosynthetic process; LOCATED IN: cytosol, apoplast, chloroplast, plasma membrane; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, seedling growth; CONTAINS InterPro DOMAIN/s: Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal (InterPro:IPR013215), Methionine synthase, vitamin-B12 independent (InterPro:IPR002629), 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (InterPro:IPR006276); BEST Arabidopsis thaliana protein match is: Cobalamin-independent synthase family protein (TAIR:AT5G17920.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_187028.1
    • methionine synthase 2 (MS2); FUNCTIONS IN: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity, methionine synthase activity; INVOLVED IN: response to cadmium ion, response to salt stress, methionine biosynthetic process; LOCATED IN: cytosol, apoplast, plasma membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, seedling growth; CONTAINS InterPro DOMAIN/s: Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal (InterPro:IPR013215), Methionine synthase, vitamin-B12 independent (InterPro:IPR002629), 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (InterPro:IPR006276); BEST Arabidopsis thaliana protein match is: Cobalamin-independent synthase family protein (TAIR:AT5G17920.2); Has 4502 Blast hits to 4490 proteins in 1700 species: Archae - 186; Bacteria - 3282; Metazoa - 14; Fungi - 208; Plants - 251; Viruses - 2; Other Eukaryotes - 559 (source: NCBI BLink).
    NP_850507.1
    • methionine synthase 2 (MS2); FUNCTIONS IN: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity, methionine synthase activity; INVOLVED IN: response to cadmium ion, response to salt stress, methionine biosynthetic process; LOCATED IN: cytosol, apoplast, plasma membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, seedling growth; CONTAINS InterPro DOMAIN/s: Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal (InterPro:IPR013215), Methionine synthase, vitamin-B12 independent (InterPro:IPR002629), 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (InterPro:IPR006276); BEST Arabidopsis thaliana protein match is: Cobalamin-independent synthase family protein (TAIR:AT5G17920.2); Has 4511 Blast hits to 4499 proteins in 1700 species: Archae - 186; Bacteria - 3291; Metazoa - 14; Fungi - 208; Plants - 251; Viruses - 2; Other Eukaryotes - 559 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      956862..961032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180176.4 → NP_850507.1  methionine synthase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850507.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94BN4, Q9SRV5
      UniProtKB/TrEMBL
      A0A178VKB3, A0A5S9X8U3, A0A654F3V2
      Conserved Domains (1) summary
      PLN02475
      Location:1 → 765
      PLN02475; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

    2. NM_111249.5 → NP_187028.1  methionine synthase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187028.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94BN4, Q9SRV5
      UniProtKB/TrEMBL
      A0A178VKB3, A0A5S9X8U3, A0A654F3V2
      Conserved Domains (1) summary
      PLN02475
      Location:1 → 765
      PLN02475; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

    3. NM_001125092.1 → NP_001118564.1  methionine synthase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118564.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94BN4, Q9SRV5
      UniProtKB/TrEMBL
      A0A178VKB3, A0A5S9X8U3, A0A654F3V2
      Conserved Domains (1) summary
      PLN02475
      Location:1 → 765
      PLN02475; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SRV5.1

    Gene LinkOut

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