zfh2 Zn finger homeodomain 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: zfh2provided by FlyBase
Official Full Name: Zn finger homeodomain 2provided by FlyBase
Primary source: FLYBASE:FBgn0004607
Locus tag: Dmel_CG1449
See related: AllianceGenome:FB:FBgn0004607
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1449; Dmel\CG1449; zfh-2; Zfh-2; ZFH-2; Zfh2; ZFH2
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in imaginal disc-derived wing morphogenesis and nervous system development. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; imaginal disc; larval neurons; longitudinal glial cell; and somatic precursor cell. Human ortholog(s) of this gene implicated in several diseases, including Marsili syndrome; familial atrial fibrillation; hepatocellular carcinoma; lung non-small cell carcinoma (multiple); and spinocerebellar ataxia type 4. Orthologous to several human genes including ZFHX3 (zinc finger homeobox 3) and ZFHX4 (zinc finger homeobox 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 102C3-102C4; 4-0 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (501810..540874)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (522436..561500)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZFH-2 is required for Drosophila ovarian follicle development and is expressed at the band/interband boundaries of polytene chromosomes.
Title: ZFH-2 is required for Drosophila ovarian follicle development and is expressed at the band/interband boundaries of polytene chromosomes.
Zfh-2 facilitates Notch-induced apoptosis in the CNS and appendages of Drosophila melanogaster.
Title: Zfh-2 facilitates Notch-induced apoptosis in the CNS and appendages of Drosophila melanogaster.
Study identifies the cascade of cellular changes and regulatory steps that control differentiation in the adult fly midgut and identifies zfh2 as a major player in these processes.
Title: zfh2 controls progenitor cell activation and differentiation in the adult Drosophila intestinal absorptive lineage.
these results identify Zfh2 as the first in vivo mediator of hypercapnic immune suppression.
Title: Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen.
results demonstrate the key role of zfh-2 in the control of cell death and Notch signaling during leg development
Title: The zinc finger homeodomain-2 gene of Drosophila controls Notch targets and regulates apoptosis in the tarsal segments.
Zfh2 plays an important role controlling the expression of several wing genes and in the specification of cellular properties that define the differences in cell proliferation between proximal and distal domains of the wing disc.
Title: Multiple roles of the gene zinc finger homeodomain-2 in the development of the Drosophila wing.
In discs lacking zfh2 the limits of the expression domains of the genes tsh, nub, rn, dve and nab coincide, and expression of wg in the wing hinge, is lost.
Title: The Drosophila gene zfh2 is required to establish proximal-distal domains in the wing disc.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 511460-511517 mobile_element_type = transposon:1360{}6091
Loc: 511697-511750 mobile_element_type = transposon:INE-1{}5956
Loc: 511816-511931 mobile_element_type = transposon:INE-1{}5957
Loc: 514139-514480 mobile_element_type = transposon:INE-1{}5959
Loc: 518675-518810 mobile_element_type = transposon:INE-1{}5962
Loc: 518831-518878 mobile_element_type = transposon:INE-1{}5383
Loc: 520400-520647 mobile_element_type = transposon:INE-1{}5384
Loc: 527166-527206 mobile_element_type = transposon:1360{}6092

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Zn finger homeodomain 2

Names: CG1449-PA; CG1449-PB; CG1449-PC; zfh2-PA; zfh2-PB; zfh2-PC; zinc finger homeodomain 2; zinc finger homeodomain-2; zn finger homeodomain 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

501810..540874

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258496.3 → NP_001245425.1 Zn finger homeodomain 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245425.1

Status: REVIEWED

UniProtKB/TrEMBL

H9XVP0

Conserved Domains (4) summary

smart00389
Location:1795 → 1851

HOX; Homeodomain

sd00017
Location:561 → 581

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:1515 → 1542

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00046
Location:2762 → 2814

Homeobox; Homeobox domain
NM_079884.5 → NP_524623.2 Zn finger homeodomain 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524623.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P28167, Q95SN9, Q9V4D7

Related

FBpp0088139

Conserved Domains (4) summary

smart00389
Location:1797 → 1853

HOX; Homeodomain

sd00017
Location:561 → 581

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:1515 → 1542

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00046
Location:2764 → 2816

Homeobox; Homeobox domain
NM_001272130.1 → NP_001259059.1 Zn finger homeodomain 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259059.1

Status: REVIEWED

UniProtKB/TrEMBL

L0MLK7

Conserved Domains (4) summary

smart00389
Location:1797 → 1853

HOX; Homeodomain

sd00017
Location:561 → 581

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:1515 → 1542

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00046
Location:2158 → 2210

Homeobox; Homeobox domain