U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Nep7 Neprilysin 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43356, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nep7provided by FlyBase
    Official Full Name
    Neprilysin 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0039564
    Locus tag
    Dmel_CG5527
    See related
    AllianceGenome:FB:FBgn0039564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5527; Dmel\CG5527
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nep7 in Genome Data Viewer
    Location:
    98B6-98B6; 3-94 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27954917..27957326)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23780639..23783048)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitoferrin Neighboring gene Glycoprotein 93 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in proteolysis  
    Component Evidence Code Pubs
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    neprilysin 7
    Names
    CG5527-PA
    Nep7-PA
    NP_651603.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27954917..27957326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143346.3 → NP_651603.1  neprilysin 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651603.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V584, Q9VAY0
      Related
      FBpp0084624
      Conserved Domains (2) summary
      cd08662
      Location:66 → 715
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:60 → 717
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    External link. Please review our privacy policy.