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    CLS Cardiolipin synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43104, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CLSprovided by FlyBase
    Official Full Name
    Cardiolipin synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039360
    Locus tag
    Dmel_CG4774
    See related
    AllianceGenome:FB:FBgn0039360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4774; dCLS; Dmel\CG4774
    Summary
    Enables cardiolipin synthase (CMP-forming). Predicted to be involved in cardiolipin biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 57. Orthologous to human CRLS1 (cardiolipin synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CLS in Genome Data Viewer
    Location:
    96E10-96E10; 3-88 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25685236..25687370, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21510958..21513092, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene Ribosomal protein L27 Neighboring gene Lipophorin receptor 2 Neighboring gene long non-coding RNA:CR46102 Neighboring gene Lipophorin receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of cardiac cardiolipin synthase alters systolic and diastolic function. Smeir E, et al. iScience, 2021 Nov 19. PMID 34805785, Free PMC Article
    2. Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane. Xu Y, et al. EMBO J, 2021 Dec 1. PMID 34661298, Free PMC Article
    3. Tafazzins from Drosophila and mammalian cells assemble in large protein complexes with a short half-life. Xu Y, et al. Mitochondrion, 2015 Mar. PMID 25598000, Free PMC Article
    4. Cardiolipin affects the supramolecular organization of ATP synthase in mitochondria. Acehan D, et al. Biophys J, 2011 May 4. PMID 21539786, Free PMC Article
    5. Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen. Vacaru AM, et al. J Biol Chem, 2013 Apr 19. PMID 23449981, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cardiolipin synthase (CMP-forming) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cardiolipin synthase (CMP-forming) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiolipin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of mitochondrial membrane organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cardiolipin synthase
    Names
    CG4774-PA
    CG4774-PB
    CG4774-PC
    CG4774-PD
    CLS-PA
    CLS-PB
    CLS-PC
    CLS-PD
    cardiolipin
    NP_001262969.1
    NP_651418.1
    NP_733116.1
    NP_733117.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25685236..25687370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276040.1 → NP_001262969.1  cardiolipin synthase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262969.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3F1, Q8MZC4, Q9VBN4
      UniProtKB/TrEMBL
      A0A0B4KHW4
      Conserved Domains (1) summary
      COG0558
      Location:125 → 316
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

    2. NM_170237.2 → NP_733116.1  cardiolipin synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3F1, Q8MZC4, Q9VBN4
      UniProtKB/TrEMBL
      A0A0B4KHW4
      Related
      FBpp0084303
      Conserved Domains (1) summary
      COG0558
      Location:125 → 316
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

    3. NM_143161.2 → NP_651418.1  cardiolipin synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651418.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3F1, Q8MZC4, Q9VBN4
      UniProtKB/TrEMBL
      A0A0B4KHW4
      Related
      FBpp0084304
      Conserved Domains (1) summary
      COG0558
      Location:125 → 316
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

    4. NM_170238.2 → NP_733117.1  cardiolipin synthase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733117.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3F1, Q8MZC4, Q9VBN4
      UniProtKB/TrEMBL
      A0A0B4KHW4
      Related
      FBpp0084305
      Conserved Domains (1) summary
      COG0558
      Location:125 → 316
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHW4 A0A0B4KHW4
    Q8MZC4.1 Q8MZC4

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