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    Cby Chibby [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42574, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cbyprovided by FlyBase
    Official Full Name
    Chibbyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0067317
    Locus tag
    Dmel_CG13415
    See related
    AllianceGenome:FB:FBgn0067317
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cby; CBY; CG13415; Dmel\CG13415
    Summary
    Involved in cilium assembly and protein localization to ciliary transition zone. Located in ciliary basal body; ciliary cap; and ciliary transition zone. Colocalizes with centriole. Orthologous to human CBY1 (chibby 1, beta catenin antagonist). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cby in Genome Data Viewer
    Location:
    93F14-93F14; 3-73 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21868003..21868770)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17693725..17694492)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45645 Neighboring gene larsen Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Small changes in Wnt signalling. Greaves S. Nat Cell Biol, 2003 May. PMID 12724772
    2. Role of DZIP1-CBY-FAM92 transition zone complex in the basal body to membrane attachment and ciliary budding. Lapart JA, et al. Biochem Soc Trans, 2020 Jun 30. PMID 32491167
    3. Drosophila transition fibers are essential for IFT-dependent ciliary elongation but not basal body docking and ciliary budding. Hou Y, et al. Curr Biol, 2023 Feb 27. PMID 36669498
    4. Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway. Takemaru K, et al. Nature, 2003 Apr 24. PMID 12712206
    5. A nuclear function for armadillo/beta-catenin. Tolwinski NS, et al. PLoS Biol, 2004 Apr. PMID 15024404, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ciliary basal body-plasma membrane docking IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ciliary transition zone assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in non-motile cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to ciliary transition zone IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT involved_in regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm axoneme assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary cap IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chibby
    Names
    CG13415-PC
    CG13415-PE
    Cby-PC
    Cby-PE
    NP_001262813.1
    • deletion mutation
    NP_650989.7
    • frameshift

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21868003..21868770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142732.3 → NP_650989.7  chibby, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9A0M5, Q4V6B6, Q9VD70

    2. NM_001275884.1 → NP_001262813.1  chibby, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262813.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHL3
      Conserved Domains (1) summary
      cd07429
      Location:1 → 99
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHL3 A0A0B4KHL3
    B9A0M5 B9A0M5

    Gene LinkOut

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