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    Ktl Kctd12-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42475, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ktlprovided by FlyBase
    Official Full Name
    Kctd12-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038839
    Locus tag
    Dmel_CG10830
    See related
    AllianceGenome:FB:FBgn0038839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10830; Dmel\CG10830
    Summary
    Involved in several processes, including inter-male aggressive behavior; male courtship behavior; and negative regulation of locomotion involved in locomotory behavior. Is expressed in several structures, including adult head; adult pars intercerebralis; antennal mechanosensory and motor center; gall; and ganglia. Orthologous to several human genes including KCTD12 (potassium channel tetramerization domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ktl in Genome Data Viewer
    Location:
    93A2-93A2; 3-69 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20894452..20897320, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16720174..16723042, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Threonine-CGT 1-3 Neighboring gene long non-coding RNA:CR44947 Neighboring gene grik Neighboring gene ncRNA Neighboring gene Turandot X Neighboring gene antisense RNA:CR44106 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Kctd-family homologue Kctd12-like modulates male aggression and mating behaviour. Williams MJ, et al. Eur J Neurosci, 2014 Aug. PMID 24830553
    2. The Drosophila Small Conductance Calcium-Activated Potassium Channel Negatively Regulates Nociception. Walcott KCE, et al. Cell Rep, 2018 Sep 18. PMID 30231996, Free PMC Article
    3. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in inter-male aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kctd12-like
    Names
    CG10830-PA
    CG10830-PB
    Ktl-PA
    Ktl-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20894452..20897320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316538.1 → NP_001303467.1  Kctd12-like, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDH3
      Conserved Domains (2) summary
      smart00225
      Location:5 → 97
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cl02518
      Location:5 → 91
      BTB; BTB/POZ domain

    2. NM_142669.4 → NP_650926.1  Kctd12-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650926.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDH3
      Related
      FBpp0083390
      Conserved Domains (2) summary
      smart00225
      Location:5 → 97
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cl02518
      Location:5 → 91
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDH3 Q9VDH3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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