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    bon bonus [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bonprovided by FlyBase
    Official Full Name
    bonusprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023097
    Locus tag
    Dmel_CG5206
    See related
    AllianceGenome:FB:FBgn0023097
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0241/08; 0249/12; 0434/20; 0487/06; 150268_at; 150269_at; anon-WO0118547.418; Bon; Bonus; CG15687; CG5206; Dmel\CG5206; l(3)S043420
    Summary
    Enables chromatin binding activity. Involved in chromatin organization and epidermal cell fate specification. Located in chromatin and nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; ganglia; larval external muscle cell; multidendritic neurons; and neuron projection bundle. Orthologous to several human genes including TRIM24 (tripartite motif containing 24). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bon in Genome Data Viewer
    Location:
    92F2-92F3; 3-69 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20593139..20612540)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16418861..16438262)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46044 Neighboring gene Septin 2 Neighboring gene Signal recognition particle 72 Neighboring gene Pseudouridine synthase 1 Neighboring gene transfer RNA:Leucine-TAA 1-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Hairless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of p53: TRIM24 enters the RING. Jain AK, et al. Cell Cycle, 2009 Nov 15. PMID 19844164
    2. Rapid phenotypic analysis of uncoated Drosophila samples with low-vacuum scanning electron microscopy. Tardi NJ, et al. Fly (Austin), 2012 Jul-Sep. PMID 22722327
    3. Fruitless recruits two antagonistic chromatin factors to establish single-neuron sexual dimorphism. Ito H, et al. Cell, 2012 Jun 8. PMID 22682252
    4. Bonus, a Drosophila TIF1 homolog, is a chromatin-associated protein that acts as a modifier of position-effect variegation. Beckstead RB, et al. Genetics, 2005 Feb. PMID 15545640, Free PMC Article
    5. Towards reconstructing the dipteran demise of an ancient essential gene: E3 ubiquitin ligase Murine double minute. Jasti N, et al. Dev Genes Evol, 2020 Jul. PMID 32623522

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes.
      Title: SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes.
    2. Impact of Germline Depletion of Bonus on Chromatin State in Drosophila Ovaries.
      Title: Impact of Germline Depletion of Bonus on Chromatin State in Drosophila Ovaries.
    3. Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye.
      Title: Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye.
    4. Study shows that Fru forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a), which demasculinizes them.
      Title: Fruitless recruits two antagonistic chromatin factors to establish single-neuron sexual dimorphism.
    5. TRIM24 homolog, bonus, targets endogenous p53 for degradation.
      Title: Trim24 targets endogenous p53 for degradation.
    6. bon is a chromatin-associated protein that acts as a modifier of position-effect variegation.
      Title: Bonus, a Drosophila TIF1 homolog, is a chromatin-associated protein that acts as a modifier of position-effect variegation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 20601970-20602409 mobile_element_type = transposon:INE-1{}6205

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bonus
    Names
    CG5206-PA
    CG5206-PB
    CG5206-PC
    CG5206-PD
    CG5206-PE
    CG5206-PF
    bon-PA
    bon-PB
    bon-PC
    bon-PD
    bon-PE
    bon-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20593139..20612540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079985.4 → NP_524724.2  bonus, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524724.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3Y7, Q9VDK5
      Related
      FBpp0083320
      Conserved Domains (5) summary
      cd05502
      Location:963 → 1072
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:284 → 409
      BBC; B-Box C-terminal domain
      cd00021
      Location:239 → 275
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15541
      Location:899 → 943
      PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
      pfam14634
      Location:82 → 130
      zf-RING_5; zinc-RING finger domain

    2. NM_001275836.1 → NP_001262765.1  bonus, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262765.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGE5, Q9U3Y7
      Conserved Domains (5) summary
      cd05502
      Location:963 → 1072
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:284 → 409
      BBC; B-Box C-terminal domain
      cd00021
      Location:239 → 275
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15541
      Location:899 → 943
      PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
      pfam14634
      Location:82 → 130
      zf-RING_5; zinc-RING finger domain

    3. NM_001275838.1 → NP_001262767.1  bonus, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262767.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHT0, Q9U3Y7
      Conserved Domains (5) summary
      cd05502
      Location:955 → 1064
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:284 → 409
      BBC; B-Box C-terminal domain
      cd00021
      Location:239 → 275
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15541
      Location:891 → 935
      PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
      pfam14634
      Location:82 → 130
      zf-RING_5; zinc-RING finger domain

    4. NM_001275837.1 → NP_001262766.1  bonus, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262766.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH12, Q9U3Y7
      Conserved Domains (5) summary
      cd05502
      Location:949 → 1058
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:284 → 409
      BBC; B-Box C-terminal domain
      cd00021
      Location:239 → 275
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15541
      Location:885 → 929
      PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
      pfam14634
      Location:82 → 130
      zf-RING_5; zinc-RING finger domain

    5. NM_001275839.1 → NP_001262768.1  bonus, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262768.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHG7, Q9U3Y7
      Conserved Domains (5) summary
      cd05502
      Location:953 → 1061
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:284 → 409
      BBC; B-Box C-terminal domain
      cd00021
      Location:239 → 275
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15541
      Location:889 → 933
      PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
      pfam14634
      Location:82 → 130
      zf-RING_5; zinc-RING finger domain

    6. NM_001170194.2 → NP_001163665.1  bonus, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163665.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHL4, Q9U3Y7
      Conserved Domains (5) summary
      cd05502
      Location:955 → 1064
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:284 → 409
      BBC; B-Box C-terminal domain
      cd00021
      Location:239 → 275
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15541
      Location:891 → 935
      PHD_TIF1_like; PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins
      pfam14634
      Location:82 → 130
      zf-RING_5; zinc-RING finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGE5 A0A0B4KGE5
    A0A0B4KH12 A0A0B4KH12
    A0A0B4KHG7 A0A0B4KHG7
    A0A0B4KHT0 A0A0B4KHT0
    A8WHL4 A8WHL4
    Q9U3Y7 Q9U3Y7
    Q9VDK5 Q9VDK5

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