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    thiamine diphosphate-binding fold (THDP-binding) superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 833376, updated on 18-Sep-2024

    Summary

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    Official Full Name
    thiamine diphosphate-binding fold (THDP-binding) superfamily protein
    Primary source
    TAIR:AT5G34780
    Locus tag
    AT5G34780
    See related
    Araport:AT5G34780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T3J11.40; T3J11_40
    Summary
    Putative ketopantoate reductase (KPR). This enzyme is speculated to be the missing enzyme in the biosynthesis of pantothenate.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (12961682..12963892, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene pseudo Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. Ottenhof HH, et al. Plant J, 2004 Jan. PMID 14675432
    2. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_122867.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 2-dehydropantoate 2-reductase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pantothenate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pantothenate biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    thiamine diphosphate-binding fold (THDP-binding) superfamily protein
    NP_198327.1
    • Thiamin diphosphate-binding fold (THDP-binding) superfamily protein; FUNCTIONS IN: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, 2-dehydropantoate 2-reductase activity; INVOLVED IN: pantothenate biosynthetic process, metabolic process; LOCATED IN: endomembrane system; CONTAINS InterPro DOMAIN/s: Dehydrogenase, E1 component (InterPro:IPR001017); BEST Arabidopsis thaliana protein match is: Thiamin diphosphate-binding fold (THDP-binding) superfamily protein (TAIR:AT1G21400.1); Has 8440 Blast hits to 8438 proteins in 1755 species: Archae - 123; Bacteria - 5526; Metazoa - 482; Fungi - 237; Plants - 202; Viruses - 0; Other Eukaryotes - 1870 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      12961682..12963892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122867.1 → NP_198327.1  thiamine diphosphate-binding fold (THDP-binding) superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198327.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KIN4
      UniProtKB/TrEMBL
      A0A654G523
      Conserved Domains (2) summary
      cd02000
      Location:25 → 195
      TPP_E1_PDC_ADC_BCADC; Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain ...
      pfam04484
      Location:260 → 323
      DUF566; Family of unknown function (DUF566)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4KIN4.1

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