ORMDL Orosomucoid 1-like [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ORMDLprovided by FlyBase
Official Full Name: Orosomucoid 1-likeprovided by FlyBase
Primary source: FLYBASE:FBgn0037110
Locus tag: Dmel_CG14577
See related: AllianceGenome:FB:FBgn0037110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14577; Dmel\CG14577; dORMDL
Summary: Predicted to be involved in ceramide metabolic process; intracellular sphingolipid homeostasis; and sphingolipid biosynthetic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; germ band; imaginal disc; and synaptic neuropil domain. Used to study asthma. Orthologous to human ORMDL1 (ORMDL sphingolipid biosynthesis regulator 1); ORMDL2 (ORMDL sphingolipid biosynthesis regulator 2); and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (21635305..21636251)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (21628405..21629351)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

ORMDL deregulation increases stress responses and modulates repair pathways in Drosophila airways.
Title: ORMDL deregulation increases stress responses and modulates repair pathways in Drosophila airways.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sphingolipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of serine palmitoyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info