CapaR Capability receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CapaRprovided by FlyBase
Official Full Name: Capability receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0037100
Locus tag: Dmel_CG14575
See related: AllianceGenome:FB:FBgn0037100
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CAP2B-R; Capa R; CAPA-R; capaR; CG14575; Dm CG14575; Dmel\CG14575; PVKr
Summary: Enables neuropeptide receptor activity. Involved in cellular response to desiccation; neuropeptide signaling pathway; and positive regulation of calcium ion transport. Located in basolateral plasma membrane. Is expressed in Malpighian tubule; Malpighian tubule Type I cell; and embryonic/larval main segment of Malpighian tubule. Orthologous to human NMUR1 (neuromedin U receptor 1) and NMUR2 (neuromedin U receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (21558974..21562181, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (21552074..21555281, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila.
Title: A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila.
CapaR acts in the key fluid-transporting tissue to regulate responses to desiccation stress in the fly.
Title: Mechanism and function of Drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor.
cloning and expression of a receptor for capa-1 and capa-2 in Drosophila
Title: Molecular cloning and functional expression of a Drosophila receptor for the neuropeptides capa-1 and -2.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables neuromedin U receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in body fluid secretion	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to desiccation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: CAPA receptor; CG14575-PB; CG14575-PC; CapaR-PB; CapaR-PC; capa peptide receptor

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The following sections contain reference sequences that belong to a specific genome build. Explain