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    Ids Iduronate 2-sulfatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38423, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Idsprovided by FlyBase
    Official Full Name
    Iduronate 2-sulfataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035445
    Locus tag
    Dmel_CG12014
    See related
    AllianceGenome:FB:FBgn0035445
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey282; CG12014; Dmel\CG12014; IDS
    Summary
    Enables iduronate-2-sulfatase activity. Predicted to be involved in glycosaminoglycan catabolic process. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in mucopolysaccharidosis II. Orthologous to human IDS (iduronate 2-sulfatase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    63D2-63D2; 3-8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3378268..3380083)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3378268..3380083)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45737 Neighboring gene sprouty Neighboring gene mir-2282 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modeling Mucopolysaccharidosis Type II in the Fruit Fly by Using the RNA Interference Approach. Rigon L, et al. Life (Basel), 2020 Oct 30. PMID 33142967, Free PMC Article
    2. Comparative studies of vertebrate iduronate 2-sulfatase (IDS) genes and proteins: evolution of A mammalian X-linked gene. Holmes RS. 3 Biotech, 2017 May. PMID 28401457, Free PMC Article
    3. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. Yu M, et al. PLoS Genet, 2023 May. PMID 37200393, Free PMC Article
    4. The genetic basis and adult reproductive consequences of developmental thermal plasticity. Rodrigues LR, et al. J Anim Ecol, 2022 Jun. PMID 35060127, Free PMC Article
    5. Exploiting the Potential of Drosophila Models in Lysosomal Storage Disorders: Pathological Mechanisms and Drug Discovery. Rigon L, et al. Biomedicines, 2021 Mar 7. PMID 33800050, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables iduronate-2-sulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iduronate-2-sulfatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iduronate-2-sulfatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycosaminoglycan catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    iduronate 2-sulfatase
    Names
    CG12014-PA
    Ids-PA
    NP_647814.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3378268..3380083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139557.2 → NP_647814.1  iduronate 2-sulfatase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647814.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJ62, Q9VZP8
      Related
      FBpp0072939
      Conserved Domains (2) summary
      COG3119
      Location:21 → 509
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16030
      Location:24 → 495
      iduronate-2-sulfatase; iduronate-2-sulfatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZP8 Q9VZP8

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