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    Jhedup Juvenile hormone esterase duplication [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36779, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jhedupprovided by FlyBase
    Official Full Name
    Juvenile hormone esterase duplicationprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034076
    Locus tag
    Dmel_CG8424
    See related
    AllianceGenome:FB:FBgn0034076
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8424; Dmel\CG8424; JHE; jhedup; JHEdup
    Summary
    Enables carboxylesterase activity. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jhedup in Genome Data Viewer
    Location:
    52E5-52E5; 2-77 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16117109..16119149)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12004614..12006654)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ras-related protein interacting with calmodulin Neighboring gene Aspartyl beta-hydroxylase Neighboring gene Juvenile hormone esterase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neofunctionalization of "Juvenile Hormone Esterase Duplication" in Drosophila as an odorant-degrading enzyme towards food odorants. Steiner C, et al. Sci Rep, 2017 Oct 3. PMID 28974761, Free PMC Article
    2. The molecular basis for the neofunctionalization of the juvenile hormone esterase duplication in Drosophila. Hopkins DH, et al. Insect Biochem Mol Biol, 2019 Mar. PMID 30611903
    3. Identification of candidate odorant degrading gene/enzyme systems in the antennal transcriptome of Drosophila melanogaster. Younus F, et al. Insect Biochem Mol Biol, 2014 Oct. PMID 25038463
    4. Identification of a juvenile hormone esterase gene by matching its peptide mass fingerprint with a sequence from the Drosophila genome project. Campbell PM, et al. Insect Biochem Mol Biol, 2001 Apr 27. PMID 11267890
    5. Only one esterase of Drosophila melanogaster is likely to degrade juvenile hormone in vivo. Crone EJ, et al. Insect Biochem Mol Biol, 2007 Jun. PMID 17517331

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DmJHE has sufficient substrate promiscuity and activity against odorant esters for a duplicate to evolve a general odorant degrading esterase (ODE) function against a range of mid-long chain food esters, as is shown in DmJHEdup. Both JHEs showed very similar active sites despite low sequence identity (30%).
      Title: The molecular basis for the neofunctionalization of the juvenile hormone esterase duplication in Drosophila.
    2. An electrophysiological analysis demonstrates that ab1A olfactory neurons of jhedup mutant flies exhibit an increased response to certain food acetates. Furthermore, mutant flies show a higher sensitivity towards the same odorants in behavioural assays. A phylogenetic analysis reveals that jhedup arose as a duplication of the juvenile hormone esterase gene during the evolution of Diptera, most likely in the ancestor of Sc
      Title: Neofunctionalization of "Juvenile Hormone Esterase Duplication" in Drosophila as an odorant-degrading enzyme towards food odorants.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables juvenile-hormone esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    enables serine hydrolase activity HDA PubMed 

    General protein information

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    Preferred Names
    juvenile hormone esterase duplication
    Names
    CG8424-PA
    Jhedup-PA
    juvenile hormone esterase
    NP_611085.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16117109..16119149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137241.4 → NP_611085.2  juvenile hormone esterase duplication [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611085.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZA97, Q1W1Y0
      Conserved Domains (2) summary
      COG0657
      Location:106 → 210
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:31 → 508
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZA97 A1ZA97
    Q1W1Y0 Q1W1Y0

    Gene LinkOut

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