Cyp6g2 Cytochrome P450 6g2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cyp6g2provided by FlyBase
Official Full Name: Cytochrome P450 6g2provided by FlyBase
Primary source: FLYBASE:FBgn0033696
Locus tag: Dmel_CG8859
See related: AllianceGenome:FB:FBgn0033696
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 6g2; CG8859; cyp6g2; Cyp6G2; Dmel\CG8859
Summary: Enables farnesoate epoxidase activity and methyl farnesoate epoxidase activity. Involved in response to insecticide. Is expressed in embryonic/larval corpus allatum and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12188338..12190377, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (8075843..8077882, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Cyp6g2 is the major P450 epoxidase responsible for juvenile hormone biosynthesis in Drosophila melanogaster.
Title: Cyp6g2 is the major P450 epoxidase responsible for juvenile hormone biosynthesis in Drosophila melanogaster.
Additionally, RNA interference against RG-enriched cytochrome p450s Cyp6u1 and Cyp6g2 produced a lethal ecdysone deficiency and a juvenile hormone deficiency, respectively, flagging a critical role for these genes in hormone synthesis.
Title: Transcriptome Analysis of Drosophila melanogaster Third Instar Larval Ring Glands Points to Novel Functions and Uncovers a Cytochrome p450 Required for Development.
Transgenic flies, expressing the human ERRa-G allele, constitutively over-express Cyp12d1, Cyp6g2 and Cyp9c1.
Title: A glycine insertion in the estrogen-related receptor (ERR) is associated with enhanced expression of three cytochrome P450 genes in transgenic Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables farnesoate epoxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables methyl farnesoate epoxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in insecticide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to DDT	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to insecticide	IMP Inferred from Mutant Phenotype more info	PubMed