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    Lamtor3 Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lamtor3provided by FlyBase
    Official Full Name
    Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0032642
    Locus tag
    Dmel_CG5110
    See related
    AllianceGenome:FB:FBgn0032642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE09173; CG5110; Dmel\CG5110; dMP1; MP1
    Summary
    Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in cellular response to amino acid stimulus and positive regulation of TORC1 signaling. Part of Ragulator complex. Is expressed in several structures, including adult head; imaginal disc; and larval brain. Orthologous to human LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lamtor3 in Genome Data Viewer
    Location:
    36C10-36C10; 2-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17481231..17482037)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17481231..17482037)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene cassowary Neighboring gene four way stop Neighboring gene Glucosidase 2 beta subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of the MP1 scaffold protein in ERK signaling regulation during Drosophila wing development. Mouchel-Vielh E, et al. Genes Cells, 2008 Nov. PMID 18823331
    2. Systematic functional analysis of Bicaudal-D serine phosphorylation and intragenic suppression of a female sterile allele of BicD. Koch R, et al. PLoS One, 2009. PMID 19234596, Free PMC Article
    3. The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development. Mouchel-Vielh E, et al. BMC Dev Biol, 2011 Mar 14. PMID 21401930, Free PMC Article
    4. Critical contribution of linker proteins to Raf kinase activation. Anselmo AN, et al. J Biol Chem, 2002 Feb 22. PMID 11741918
    5. Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation. Gelbart ME, et al. Nat Struct Mol Biol, 2009 Aug. PMID 19648925, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Corto, rl and dMP1 interact during wing tissue differentiation; Corto, ERK(rl) and dMP1 form a complex in the nucleus and co-localize on several sites on polytene chromosomes
      Title: The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development.
    2. MEK Partner 1 (dMP1) functions in the control of cell differentiation during development of the Drosophila wing.
      Title: Involvement of the MP1 scaffold protein in ERK signaling regulation during Drosophila wing development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to amino acid stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Ragulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ragulator complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of Ragulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
    Names
    CG5110-PA
    CG5110-PB
    Lamtor3-PA
    Lamtor3-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17481231..17482037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259133.2 → NP_001246062.1  late endosomal/lysosomal adaptor, MAPK and MTOR activator 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246062.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJD2
      UniProtKB/TrEMBL
      M9NEQ5
      Conserved Domains (1) summary
      pfam08923
      Location:3 → 121
      MAPKK1_Int; Mitogen-activated protein kinase kinase 1 interacting

    2. NM_135999.4 → NP_609843.1  late endosomal/lysosomal adaptor, MAPK and MTOR activator 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609843.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJD2
      UniProtKB/TrEMBL
      M9NEQ5
      Related
      FBpp0080536
      Conserved Domains (1) summary
      pfam08923
      Location:3 → 121
      MAPKK1_Int; Mitogen-activated protein kinase kinase 1 interacting
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NEQ5 M9NEQ5
    Q9VJD2.1 Q9VJD2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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