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    Dad1 Defender against apoptotic cell death 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34159, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Dad1provided by FlyBase
    Official Full Name
    Defender against apoptotic cell death 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0263852
    Locus tag
    Dmel_CG13393
    See related
    AllianceGenome:FB:FBgn0263852
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE23864; CG13393; dDad1; Dmel\CG13393; l(2)k12914; OST
    Summary
    Involved in protein N-linked glycosylation. Located in endoplasmic reticulum membrane. Is expressed in adult head and adult heart. Orthologous to human DAD1 (defender against cell death 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dad1 in Genome Data Viewer
    Location:
    29B4-29B4; 2-31 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8383612..8384137, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8383612..8384137, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Alanyl-tRNA synthetase Neighboring gene uncharacterized protein Neighboring gene Reduction in Cnn dots 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U6atac

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic reticulum proteins Meigo and Gp93 govern dendrite targeting by regulating Toll-6 localization. Kamemura K, et al. Dev Biol, 2022 Apr. PMID 35134382
    2. The defender against apoptotic cell death 1 gene is required for tissue growth and efficient N-glycosylation in Drosophila melanogaster. Zhang Y, et al. Dev Biol, 2016 Dec 1. PMID 27693235
    3. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article
    4. Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity. Upadhyay A, et al. Mol Neurodegener, 2023 Sep 14. PMID 37710351, Free PMC Article
    5. RIP-seq analysis of eukaryotic Sm proteins identifies three major categories of Sm-containing ribonucleoproteins. Lu Z, et al. Genome Biol, 2014 Jan 7. PMID 24393626, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. loss of dDad1 function activates JNK signaling and blocking the JNK pathway in dDad1 knock-down tissues suppresses cell apoptosis and partially restores organ size.
      Title: The defender against apoptotic cell death 1 gene is required for tissue growth and efficient N-glycosylation in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    defender against apoptotic cell death 1
    Names
    CG13393-PA
    Dad1-PA
    lethal (2) k12914

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8383612..8384137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135378.4 → NP_609222.1  defender against apoptotic cell death 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609222.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1B2AKP8, Q9VLM5
      Related
      FBpp0079324
      Conserved Domains (1) summary
      pfam02109
      Location:5 → 112
      DAD; DAD family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLM5.1 Q9VLM5

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