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    Tehao tehao [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tehaoprovided by FlyBase
    Official Full Name
    tehaoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026760
    Locus tag
    Dmel_CG7121
    See related
    AllianceGenome:FB:FBgn0026760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7121; CT22017; Dmel\CG7121; dTLR5; dToll5; tehao; Tho; Tl-5; toll; Toll 5; Toll-5; Toll5
    Summary
    Enables Toll binding activity; coreceptor activity; and protein kinase binding activity. Involved in Toll signaling pathway; antifungal innate immune response; and positive regulation of antimicrobial peptide biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including embryonic/larval dorsal vessel; embryonic/larval salivary gland; gut section; keyhole structure; and ovary. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4) and TLR5 (toll like receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tehao in Genome Data Viewer
    Location:
    34C1-34C1; 2-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13435622..13439930)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13435622..13439930)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45683 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene Heat shock protein 60D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapidly Evolving Toll-3/4 Genes Encode Male-Specific Toll-Like Receptors in Drosophila. Levin TC, et al. Mol Biol Evol, 2017 Sep 1. PMID 28541576, Free PMC Article
    2. Linkage disequilibrium and recent selection at three immunity receptor loci in Drosophila simulans. Schlenke TA, et al. Genetics, 2005 Apr. PMID 15654108, Free PMC Article
    3. The Role of Toll and Nonnuclear NF-κB Signaling in the Response to Alcohol. Atkinson NS. Cells, 2023 May 30. PMID 37296629, Free PMC Article
    4. Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling. Lin KY, et al. Nat Commun, 2020 Jun 19. PMID 32561720, Free PMC Article
    5. Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity. Luo C, et al. Insect Mol Biol, 2001 Oct. PMID 11881810

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hmu, Sr-CI/Sr-CIII, and Tehao have polymorphic sites in nearly perfect linkage disequilibrium
      Title: Linkage disequilibrium and recent selection at three immunity receptor loci in Drosophila simulans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Toll binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables coreceptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Toll signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Toll signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in antifungal innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antimicrobial peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tehao
    Names
    CG7121-PA
    CG7121-PB
    Tehao-PA
    Tehao-PB
    Toll-5
    toll 5
    toll receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13435622..13439930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298972.1 → NP_001285901.1  tehao, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285901.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NBK8, Q9VJX9
      Conserved Domains (5) summary
      smart00255
      Location:643 → 779
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:261 → 370
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:185 → 207
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:486 → 521
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:309 → 368
      LRR_8; Leucine rich repeat

    2. NM_058090.4 → NP_477438.1  tehao, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477438.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NBK8, Q9VJX9
      Related
      FBpp0080080
      Conserved Domains (5) summary
      smart00255
      Location:643 → 779
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:261 → 370
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:185 → 207
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:486 → 521
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:309 → 368
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58S70 Q58S70
    Q58S71 Q58S71
    Q58S76 Q58S76
    Q58SL2 Q58SL2
    Q58SL5 Q58SL5
    Q58SL6 Q58SL6
    Q58SL7 Q58SL7
    Q58SL8 Q58SL8
    Q9NBK8 Q9NBK8
    Q9VJX9 Q9VJX9
    Q9XZF9 Q9XZF9

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