vkg viking [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: vkgprovided by FlyBase
Official Full Name: vikingprovided by FlyBase
Primary source: FLYBASE:FBgn0016075
Locus tag: Dmel_CG16858
See related: AllianceGenome:FB:FBgn0016075
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1209; 6072; alpha(IV)2/vkg; CG16858; Col IV; col4a2; COL4A2; colIV; ColIV; ColIValpha2; Coll IV; Coll IValpha2; coll-IV; coll. IV; collagen-IV; collagenIV; CT25584; DmColA2; Dmel\CG16858; l(2)01209; veg; Vkg; VkgC
Summary: Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in Malpighian tubule development; basement membrane organization; and somatic muscle development. Located in basement membrane. Is expressed in several structures, including adult CNS glial cell; adult head; embryonic/larval hemocyte; gut section; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in brain small vessel disease 1; myocardial infarction; retinal arterial tortuosity; and uterine fibroid. Orthologous to human COL4A1 (collagen type IV alpha 1 chain). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5012144..5028191, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5012144..5028191, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IC Inferred by Curator more info	PubMed
enables extracellular matrix structural constituent	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent conferring tensile strength	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
part_of collagen type IV trimer	NAS Non-traceable Author Statement more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

Names: CG16858-PA; CG16858-PB; CG16858-PC; CollagenIV; collagen IV; collagen IV alpha2; collagen IVa2; collagenIV a2; type IV collagen; type IV collagen, alpha-chain; type IV collagenS; vkg-PA; vkg-PB; vkg-PC

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The following sections contain reference sequences that belong to a specific genome build. Explain