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    E2f1 E2F transcription factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42550, updated on 17-Dec-2024

    Summary

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    Official Symbol
    E2f1provided by FlyBase
    Official Full Name
    E2F transcription factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0011766
    Locus tag
    Dmel_CG6376
    See related
    AllianceGenome:FB:FBgn0011766
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6376; dE2f; dE2F; de2f1; dE2f1; dE2F1; def21; DmE2F-1; Dmel\CG6376; Dp; drosE2F1; DRTF1/E2F; E(Sev-CycE)3A; E(var)3-93E; E(var)3-95E; E(var)93E; e2f; E2f; E2F; E2F-1; e2f1; E2F1; Evar(3)164; l(3)07172; l(3)j3B1; l(3)j3C2; l(3)rM729
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including DNA endoreduplication; cellular response to gamma radiation; and regulation of gene expression. Located in nucleus. Part of Rb-E2F complex. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; gut section; head epidermis primordium; and nephrocyte. Used to study prostate cancer. Human ortholog(s) of this gene implicated in lung carcinoma (multiple); osteosarcoma; and pancreatic adenocarcinoma (multiple). Orthologous to several human genes including E2F1 (E2F transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See E2f1 in Genome Data Viewer
    Location:
    93E9-93F1; 3-72 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21620304..21660871, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17446026..17486593, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Insulin-like receptor Neighboring gene Insulin receptor-associated lncRNA Neighboring gene long non-coding RNA:CR44034 Neighboring gene mir-998 stem loop Neighboring gene mir-11 stem loop Neighboring gene antisense RNA:CR46055 Neighboring gene long non-coding RNA:CR46056 Neighboring gene long non-coding RNA:CR46057 Neighboring gene archease Neighboring gene Juvenile hormone binding protein 16 Neighboring gene DNA polymerase alpha subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional properties of a Drosophila homolog of the E2F1 gene. Ohtani K, et al. Mol Cell Biol, 1994 Mar. PMID 8114698, Free PMC Article
    2. Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy. Bervoets S, et al. Nat Commun, 2019 Nov 6. PMID 31695036, Free PMC Article
    3. DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Dynlacht BD, et al. Proc Natl Acad Sci U S A, 1994 Jul 5. PMID 8022787, Free PMC Article
    4. The endocycle restores tissue tension in the Drosophila abdomen post wound repair. Losick VP, et al. Cell Rep, 2021 Oct 12. PMID 34644579, Free PMC Article
    5. The E2F family: specific functions and overlapping interests. Attwooll C, et al. EMBO J, 2004 Dec 8. PMID 15538380, Free PMC Article

    See all (468) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E2F1, DIAP1, and the presence of a homologous chromosome promote while JNK inhibits radiation-induced loss of heterozygosity in Drosophila melanogaster.
      Title: E2F1, DIAP1, and the presence of a homologous chromosome promote while JNK inhibits radiation-induced loss of heterozygosity in Drosophila melanogaster.
    2. Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells.
      Title: Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells.
    3. Normal cell cycle progression requires negative regulation of E2F1 by Groucho during S phase and its relief at G2 phase.
      Title: Normal cell cycle progression requires negative regulation of E2F1 by Groucho during S phase and its relief at G2 phase.
    4. E2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development.
      Title: E2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development.
    5. Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.
      Title: Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.
    6. Proper CycE-Cdk2 activity in endocycling tissues requires regulation of the cyclin-dependent kinase inhibitor Dacapo by dE2F1b in Drosophila.
      Title: Proper CycE-Cdk2 activity in endocycling tissues requires regulation of the cyclin-dependent kinase inhibitor Dacapo by dE2F1b in Drosophila.
    7. Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.
      Title: Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.
    8. dE2F1b is a novel member of the E2F family, revealing a previously unappreciated complexity in the Drosophila RB/E2F network.
      Title: An alternatively spliced form affecting the Marked Box domain of Drosophila E2F1 is required for proper cell cycle regulation.
    9. specific alternate transcripts of activator E2F, dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor
      Title: Alternate transcripts of the Drosophila "activator" E2F are necessary for maintenance of cell cycle exit during development.
    10. These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.
      Title: E2F function in muscle growth is necessary and sufficient for viability in Drosophila.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA endoreduplication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eggshell chorion gene amplification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in larval lymph gland hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nurse cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of hemocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rb-E2F complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E2F transcription factor 1
    Names
    CG6376-PA
    CG6376-PB
    CG6376-PC
    CG6376-PD
    CG6376-PE
    CG6376-PF
    E2-promoter binding factor
    E2F transcription factor
    E2f1-PA
    E2f1-PB
    E2f1-PC
    E2f1-PD
    E2f1-PE
    E2f1-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21620304..21660871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300526.1 → NP_001287455.1  E2F transcription factor 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287455.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77035, Q27368, Q5U0Z6
      UniProtKB/TrEMBL
      A0A0B4LHG1
      Conserved Domains (2) summary
      cd14660
      Location:327 → 428
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:256 → 318
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    2. NM_169962.3 → NP_732647.1  E2F transcription factor 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732647.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77035, Q27368, Q5U0Z6
      UniProtKB/TrEMBL
      A0A0B4LHG1
      Related
      FBpp0083517
      Conserved Domains (2) summary
      cd14660
      Location:327 → 428
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:256 → 318
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    3. NM_001300525.1 → NP_001287454.1  E2F transcription factor 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287454.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGM3
      Conserved Domains (3) summary
      cd14660
      Location:327 → 362
      E2F_DD; coiled coil [structural motif]
      pfam02319
      Location:256 → 318
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      cl22411
      Location:327 → 444
      E2F_DD; Dimerization domain of E2F transcription factors

    4. NM_169961.3 → NP_732646.1  E2F transcription factor 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732646.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77035, Q27368, Q5U0Z6
      UniProtKB/TrEMBL
      A0A0B4LHG1
      Related
      FBpp0083516
      Conserved Domains (2) summary
      cd14660
      Location:327 → 428
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:256 → 318
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    5. NM_079713.3 → NP_524437.2  E2F transcription factor 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524437.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77035, Q27368, Q5U0Z6
      UniProtKB/TrEMBL
      A0A0B4LHG1
      Related
      FBpp0083518
      Conserved Domains (2) summary
      cd14660
      Location:327 → 428
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:256 → 318
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    6. NM_001275880.2 → NP_001262809.1  E2F transcription factor 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGM3
      Conserved Domains (3) summary
      cd14660
      Location:327 → 362
      E2F_DD; coiled coil [structural motif]
      pfam02319
      Location:256 → 318
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      cl22411
      Location:327 → 444
      E2F_DD; Dimerization domain of E2F transcription factors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGM3 A0A0B4KGM3
    A0A0B4LHG1 A0A0B4LHG1
    Q27368.2 Q27368
    Q8T0P0 Q8T0P0

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