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    ITN1 Ankyrin repeat family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820414, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ITN1
    Official Full Name
    Ankyrin repeat family protein
    Primary source
    TAIR:AT3G12360
    Locus tag
    AT3G12360
    See related
    Araport:AT3G12360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    INCREASED TOLERANCE TO NACL
    Summary
    Encodes a protein with an ankyrin motif and transmembrane domains that is involved in salt tolerance. Expressed throughout the plant and localized to the plasma membrane. Loss of function mutations show an increased tolerance to salt based on assaying seedling growth in the presence of salt. In the mutants, induction of genes required for production of reactive oxygen species is reduced suggesting that itn1 promotes ROS production. It interacts with RCN1 in vivo and may regulate its subcellular localization.
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    Genomic context

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    See ITN1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (3934000..3936758)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene FKBP-type peptidyl-prolyl cis-trans isomerase Neighboring gene F-box family protein Neighboring gene Ribosomal protein L10 family protein Neighboring gene actin-related protein 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction between a plasma membrane-localized ankyrin-repeat protein ITN1 and a nuclear protein RTV1. Sakamoto H, et al. Biochem Biophys Res Commun, 2012 Jun 29. PMID 22664102
    2. ITN1, a novel gene encoding an ankyrin-repeat protein that affects the ABA-mediated production of reactive oxygen species and is involved in salt-stress tolerance in Arabidopsis thaliana. Sakamoto H, et al. Plant J, 2008 Nov. PMID 18643991
    3. Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Elrouby N, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20855607, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings suggest that RTV1 and ITN1 regulate the subcellular localization of each other.
      Title: Interaction between a plasma membrane-localized ankyrin-repeat protein ITN1 and a nuclear protein RTV1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001337990.1
    NM_112071.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ankyrin repeat family protein
    NP_187842.1
    • INCREASED TOLERANCE TO NACL (ITN1); INVOLVED IN: response to salt stress; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ankyrin repeat-containing domain (InterPro:IPR020683), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: Ankyrin repeat family protein (TAIR:AT3G09550.1); Has 61607 Blast hits to 26705 proteins in 1191 species: Archae - 49; Bacteria - 5778; Metazoa - 28187; Fungi - 6605; Plants - 4929; Viruses - 594; Other Eukaryotes - 15465 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3934000..3936758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112071.3 → NP_187842.1  Ankyrin repeat family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187842.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LED2, Q9C7A2
      UniProtKB/TrEMBL
      A0A5S9XCT0, A0A654F7H2
      Conserved Domains (3) summary
      sd00045
      Location:235 → 263
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:236 → 321
      Ank_2; Ankyrin repeats (3 copies)
      pfam13962
      Location:413 → 519
      PGG; Domain of unknown function

    2. NM_001337990.1 → NP_001326831.1  Ankyrin repeat family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V8T3, A0A1I9LQG8, A0A384LMN5, A0A5S9XCT0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C7A2.1

    Gene LinkOut

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