U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    EMC1 ER membrane protein complex subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40933, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    EMC1provided by FlyBase
    Official Full Name
    ER membrane protein complex subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037530
    Locus tag
    Dmel_CG2943
    See related
    AllianceGenome:FB:FBgn0037530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2943; Dmel\CG2943; emc1; NEST:bs09f06
    Summary
    Contributes to membrane insertase activity. Involved in tail-anchored membrane protein insertion into ER membrane. Located in endomembrane system. Is expressed in adult head; adult midgut enterocyte; enteroblast; and enteroendocrine cell. Used to study cerebellar atrophy, visual impairment, and psychomotor retardation and intestinal cancer. Human ortholog(s) of this gene implicated in cerebellar atrophy, visual impairment, and psychomotor retardation. Orthologous to human EMC1 (ER membrane protein complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See EMC1 in Genome Data Viewer
    Location:
    84E4-84E5; 3-48 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7903030..7907363, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3728752..3733085, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Arginyl-tRNA synthetase, mitochondrial Neighboring gene mitochondrial ribosomal protein S9 Neighboring gene water witch Neighboring gene TBP-associated factor 7 Neighboring gene Phosphoribosylamidotransferase Neighboring gene Riboflavin kinase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. De novo variants in EMC1 lead to neurodevelopmental delay and cerebellar degeneration and affect glial function in Drosophila. Chung HL, et al. Hum Mol Genet, 2022 Sep 29. PMID 35234901, Free PMC Article
    2. EMC1 Is Required for the Sarcoplasmic Reticulum and Mitochondrial Functions in the Drosophila Muscle. Couto-Lima CA, et al. Biomolecules, 2024 Oct 5. PMID 39456191, Free PMC Article
    3. Exploiting fly models to investigate rare human neurological disorders. Tanaka T, et al. Neural Regen Res, 2025 Jan 1. PMID 38767473, Free PMC Article
    4. An EMC-Hpo-Yki axis maintains intestinal homeostasis under physiological and pathological conditions. Shi L, et al. Development, 2023 Dec 15. PMID 38031990
    5. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Xiong L, et al. Cell Death Differ, 2020 Feb. PMID 31263175, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to membrane insertase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tail-anchored membrane protein insertion into ER membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ER membrane protein complex subunit 1
    Names
    CG2943-PA
    CG2943-PB
    CG2943-PC
    CG2943-PD
    EMC1-PA
    EMC1-PB
    EMC1-PC
    EMC1-PD
    ER membrane protein complex 1
    endoplasmic reticulum membrane protein complex 1
    subunit 1 of EMC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7903030..7907363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300287.1 → NP_001287216.1  ER membrane protein complex subunit 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287216.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGV1
      Conserved Domains (1) summary
      pfam07774
      Location:702 → 907
      DUF1620; Protein of unknown function (DUF1620)

    2. NM_001300286.1 → NP_001287215.1  ER membrane protein complex subunit 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287215.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHY6
      Conserved Domains (1) summary
      pfam07774
      Location:709 → 914
      DUF1620; Protein of unknown function (DUF1620)

    3. NM_001300288.1 → NP_001287217.1  ER membrane protein complex subunit 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287217.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGV1
      Conserved Domains (1) summary
      pfam07774
      Location:702 → 907
      DUF1620; Protein of unknown function (DUF1620)

    4. NM_141490.2 → NP_649747.1  ER membrane protein complex subunit 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649747.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHY6
      Related
      FBpp0081262
      Conserved Domains (1) summary
      pfam07774
      Location:709 → 914
      DUF1620; Protein of unknown function (DUF1620)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGV1 A0A0B4LGV1
    Q95TQ6 Q95TQ6
    Q9VHY6 Q9VHY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools