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    Bdbt Bride of doubletime [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42503, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bdbtprovided by FlyBase
    Official Full Name
    Bride of doubletimeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038857
    Locus tag
    Dmel_CG17282
    See related
    AllianceGenome:FB:FBgn0038857
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bdbt; BDBT; CG17282; Dmel\CG17282
    Summary
    Enables kinase activator activity. Involved in several processes, including locomotor rhythm; regulation of establishment of planar polarity; and regulation of protein metabolic process. Located in cytosol. Is expressed in inner photoreceptor cell; outer photoreceptor cell; and retina. Orthologous to human TTC9C (tetratricopeptide repeat domain 9C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bdbt in Genome Data Viewer
    Location:
    93B13-93B13; 3-70 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21117857..21118856, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16943579..16944578, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tetracycline resistance Neighboring gene Rab11 Neighboring gene peter pan Neighboring gene supernumerary limbs Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 93a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of casein kinase I in the Drosophila circadian clock. Price JL, et al. Methods Enzymol, 2015. PMID 25662457
    2. The Circadian tau Mutation in Casein Kinase 1 Is Part of a Larger Domain That Can Be Mutated to Shorten Circadian Period. Venkatesan A, et al. Int J Mol Sci, 2019 Feb 14. PMID 30769795, Free PMC Article
    3. A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function. Venkatesan A, et al. J Biol Rhythms, 2015 Aug. PMID 26082158, Free PMC Article
    4. Noncanonical FK506-binding protein BDBT binds DBT to enhance its circadian function and forms foci at night. Fan JY, et al. Neuron, 2013 Nov 20. PMID 24210908, Free PMC Article
    5. Visual and circadian regulation of Drosophila BDBT and BDBT effects on DBT and PER localization. Nolan RB, et al. iScience, 2023 Apr 21. PMID 36994075, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables peptidyl-prolyl cis-trans isomerase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment of planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of post-translational protein modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bride of doubletime
    Names
    Bdbt-PA
    CG17282-PA
    bride of dbt

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21117857..21118856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142686.3 → NP_650943.1  bride of doubletime [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650943.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VDE4
      Related
      FBpp0083435
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDE4 Q9VDE4
    Q9VDE4.1

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