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    AOX2 Aldehyde oxidase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AOX2provided by FlyBase
    Official Full Name
    Aldehyde oxidase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038348
    Locus tag
    Dmel_CG18519
    See related
    AllianceGenome:FB:FBgn0038348
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18519; DmAO2; Dmel\CG18519
    Summary
    Enables aldehyde oxidase activity. Involved in cellular aldehyde metabolic process. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AOX2 in Genome Data Viewer
    Location:
    88F7-88F7; 3-57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15537713..15542414, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11363435..11368136, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Aldehyde oxidase 1 Neighboring gene Aldehyde oxidase 3 Neighboring gene Aldehyde oxidase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The four aldehyde oxidases of Drosophila melanogaster have different gene expression patterns and enzyme substrate specificities. Marelja Z, et al. J Exp Biol, 2014 Jun 15. PMID 24737760, Free PMC Article
    2. Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1. Terao M, et al. J Biol Chem, 2001 Dec 7. PMID 11562361
    3. Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. Sharma A, et al. Chemosphere, 2011 Jan. PMID 21036383
    4. Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism. Marelja Z, et al. Front Physiol, 2018. PMID 29491838, Free PMC Article
    5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aldehyde metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aldehyde oxidase 2
    Names
    AOX2-PC
    CG18519-PC
    NP_732047.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15537713..15542414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169665.3 → NP_732047.2  aldehyde oxidase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732047.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IND5
      Conserved Domains (7) summary
      smart01008
      Location:548 → 655
      Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
      PLN02906
      Location:24 → 1251
      PLN02906; xanthine dehydrogenase
      cd00207
      Location:3 → 84
      fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...
      pfam01799
      Location:86 → 159
      Fer2_2; [2Fe-2S] binding domain
      pfam02738
      Location:702 → 1184
      Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
      pfam03450
      Location:391 → 497
      CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain
      cl19922
      Location:206 → 366
      FAD_binding_4; FAD binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IND5 Q8IND5

    Gene LinkOut

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