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    AN3 SSXT family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832968, updated on 20-Sep-2024

    Summary

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    Official Symbol
    AN3
    Official Full Name
    SSXT family protein
    Primary source
    TAIR:AT5G28640
    Locus tag
    AT5G28640
    See related
    Araport:AT5G28640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ANGUSTIFOLIA 3; ARABIDOPSIS GRF1-INTERACTING FACTOR 1; ATGIF1; F4I4.20; F4I4_20; GIF; GIF1; GRF1-INTERACTING FACTOR; GRF1-INTERACTING FACTOR 1
    Summary
    Encodes a protein with similarity to mammalian transcriptional coactivator that is involved in cell proliferation during leaf and flower development. Loss of function mutations have narrow, pointed leaves and narrow floral organs. AN3 interacts with members of the growth regulating factor (GRF) family of transcription factors.
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    Genomic context

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    See AN3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (10647467..10650066, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ANGUSTIFOLIA3 plays roles in adaxial/abaxial patterning and growth in leaf morphogenesis. Horiguchi G, et al. Plant Cell Physiol, 2011 Jan. PMID 21097896
    2. an3-Mediated Compensation Is Dependent on a Cell-Autonomous Mechanism in Leaf Epidermal Tissue. Nozaki M, et al. Plant Cell Physiol, 2020 Jun 1. PMID 32321167
    3. Transcriptional repression of GIF1 by the KIX-PPD-MYC repressor complex controls seed size in Arabidopsis. Liu Z, et al. Nat Commun, 2020 Apr 15. PMID 32296056, Free PMC Article
    4. Arabidopsis ANGUSTIFOLIA3 (AN3) is associated with the promoter of CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) to regulate light-mediated stomatal development. Meng LS, et al. Plant Cell Environ, 2018 Jul. PMID 29645276
    5. ANGUSTIFOLIA3 signaling coordinates proliferation between clonally distinct cells in leaves. Kawade K, et al. Curr Biol, 2013 May 6. PMID 23602479

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis AN3 and OLIGOCELLULA genes link telomere maintenance mechanisms with cell division and expansion control.
      Title: Arabidopsis AN3 and OLIGOCELLULA genes link telomere maintenance mechanisms with cell division and expansion control.
    2. The SOD7/DPA4-GIF1 module coordinates organ growth and iron uptake in Arabidopsis.
      Title: The SOD7/DPA4-GIF1 module coordinates organ growth and iron uptake in Arabidopsis.
    3. PIF7 controls leaf cell proliferation through an AN3 substitution repression mechanism.
      Title: PIF7 controls leaf cell proliferation through an AN3 substitution repression mechanism.
    4. an3-Mediated Compensation Is Dependent on a Cell-Autonomous Mechanism in Leaf Epidermal Tissue.
      Title: an3-Mediated Compensation Is Dependent on a Cell-Autonomous Mechanism in Leaf Epidermal Tissue.
    5. Results reveal a genetic and molecular mechanism by which the transcription factors MYC3/4 recruit KIX8/9 and PPD1/2 to the promoter of GIF1 and repress its expression, thereby determining seed size in Arabidopsis.
      Title: Transcriptional repression of GIF1 by the KIX-PPD-MYC repressor complex controls seed size in Arabidopsis.
    6. transcriptional repression and activation mediated by the WOX, LUG and AN3 regulators function in concert to promote leaf and flower development.
      Title: Control of leaf blade outgrowth and floral organ development by LEUNIG, ANGUSTIFOLIA3 and WOX transcriptional regulators.
    7. associated with the promoter of CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) to regulate light-mediated stomatal development
      Title: Arabidopsis ANGUSTIFOLIA3 (AN3) is associated with the promoter of CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) to regulate light-mediated stomatal development.
    8. GRF-GIF duo regulates the meristematic and pluripotent competence of carpel margin meristems.
      Title: GROWTH-REGULATING FACTOR and GRF-INTERACTING FACTOR Specify Meristematic Cells of Gynoecia and Anthers.
    9. Rice MKB3 and Arabidopsis AN3 have conserved functions and effects on leaf development
      Title: Conserved functional control, but distinct regulation, of cell proliferation in rice and Arabidopsis leaves revealed by comparative analysis of GRF-INTERACTING FACTOR 1 orthologs.
    10. AN3 and YDA mutations both disrupt normal sucrose and glucose contents and cause altered seed size in an3 or yda mutants.
      Title: Soluble Sugar Accumulation Can Influence Seed Size via AN3-YDA Gene Cascade.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344077.1
    NM_001344078.1
    NM_122747.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adaxial/abaxial pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cotyledon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within root meristem growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SSXT family protein
    NP_198216.2
    • ANGUSTIFOLIA 3 (AN3); CONTAINS InterPro DOMAIN/s: SSXT (InterPro:IPR007726); BEST Arabidopsis thaliana protein match is: GRF1-interacting factor 3 (TAIR:AT4G00850.1); Has 1752 Blast hits to 1579 proteins in 197 species: Archae - 0; Bacteria - 58; Metazoa - 1009; Fungi - 145; Plants - 200; Viruses - 1; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      10647467..10650066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122747.4 → NP_198216.2  SSXT family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198216.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L8A5
      UniProtKB/TrEMBL
      A0A178UHP3, A0A5S9Y8I3
      Conserved Domains (1) summary
      pfam05030
      Location:20 → 73
      SSXT; SSXT protein (N-terminal region)

    2. NM_001344077.1 → NP_001332659.1  SSXT family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1R7T3A9

    3. NM_001344078.1 → NP_001332660.1  SSXT family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1R7T3A9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L8A5.1

    Gene LinkOut

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